GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE Chemical Properties

Melting point:

>182°C (dec.)

storage temp. 

−20°C

solubility 

chloroform/methanol (9:1): 10 mg/mL, clear, colorless

form 

lyophilized powder

color 

Off-White

Merck 

14,4364

InChIKey

GTTLZSUWCRJZRC-CRQBLQEMSA-N

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

RTECS 

FK1200000

F 

10-21

HS Code 

29400090

MSDS

• Language:English Provider:SigmaAldrich

GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE Usage And Synthesis

Chemical Properties

Off-white powder

Uses

Ganglioside GM1 (Ovine Brain) has been used in the preparation of small unilamellar vesicles for fluorescence studies. It has also been used in liposome preparation for circular dichroism studies with human wild type?synuclein. It may be used as a standard lipid for electrospray ionization (ESI) mass spectrometry (MS) analysis.

Definition

ChEBI: A sialotetraosylceramide consisting of a branched pentasaccharide made up from one sialyl residue, two galactose residues, one N-acetylgalactosamine residue and a glucose residue at the reducing end attached to N-stear ylsphingosine via a beta-linkage.

General Description

Ganglioside GM1 is referred as brain ganglioside. It is an acidic glycosphingolipid comprising N-acetylneuraminic acid or N-glycolylneuraminic acid residues. It is upregulated in developing brain. Ganglioside GM1 has five glycosyl units.

Biochem/physiol Actions

Ganglioside GM1 is a modulator of Ca2+ flux in plasmamembrane. It plays a key role in neuronal development and maturation and has neuroprotective functionality. GM1 ganglioside from ovine has many pharmaceutical applications and is regarded as an effective therapeutic for Huntington′s disease. Accumulation of GM1 in brain due to β-galactosidase enzyme deficiency is implicated in metabolic disorder, GM1 gangliosidosis.

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