PROPICILLIN
PROPICILLIN Basic information
- Product Name:
- PROPICILLIN
- Synonyms:
-
- PROPICILLIN
- (2S,5β)-3,3-Dimethyl-7-oxo-6α-[(1-oxo-2-phenoxybutyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid
- 3,3-dimethyl-7-oxo-6-[2-(phenoxy)butanoylamino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- 7-keto-3,3-dimethyl-6-[2-(phenoxy)butanoylamino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- (1-phenoxypropyl)penicillin
- α-phenoxypropylpenicillin
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(1-oxo-2-phenoxybutyl)amino]-, (2S,5R,6R)-
- PROPICILLIN USP/EP/BP
- CAS:
- 551-27-9
- MF:
- C18H22N2O5S
- MW:
- 378.44
- EINECS:
- 208-995-5
- Mol File:
- 551-27-9.mol
PROPICILLIN Chemical Properties
- pka
- pKa 2.72±0.04(H2O t=25 c=0.01) (Uncertain)
PROPICILLIN Usage And Synthesis
Description
Propicillin was synthesized by a collaboration of Beecham Research Laboratories with Bristol-Myers Laboratories in 1961 starting with 6-aminopenicillanic acid. It is stable against gastric acid and shows three- to fourfold higher serum concentrations than phenoxymethyl-penicillin when administered orally. Its antibacterial spectrum and activity are almost the same as those of phenoxymethylpenicillin. Propicillin has been used for therapy of infections caused by Streptococcus, Staphylococcus, and Neisseria.
Uses
Propicillin, is a derivative of penicillin. Properties are similar to benzylpenicillin particularly used in streptococcal infections, not resistant to penicillinase.
Definition
ChEBI: Propicillin is a penicillin. It is a conjugate acid of a propicillin(1-).