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(-)-alpha-bisabolol

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(-)-alpha-bisabolol Basic information

Product Name:
(-)-alpha-bisabolol
Synonyms:
  • A-(-)-BISABOLOL
  • CAMILLOL
  • BISABOLOL, A-(-)-
  • BISABOLOL OXIDE A
  • DRAGOSANTOL
  • HYDAGEN B
  • LEVOMENOL
  • theta)]-thet
CAS:
23089-26-1
MF:
C15H26O
MW:
222.37
EINECS:
245-423-3
Product Categories:
  • Miscellaneous Natural Products
Mol File:
23089-26-1.mol
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(-)-alpha-bisabolol Chemical Properties

alpha 
D -55.7°; D20 -51.02° (Günther)
Boiling point:
bp12 153°
Density 
d20 0.9211
vapor pressure 
0.015Pa at 20℃
refractive index 
n20/D 1.496
FEMA 
4666 | ALPHA-BISABOLOL
Flash point:
135 °C
storage temp. 
-20°C
solubility 
DMSO:100.0(Max Conc. mg/mL);449.7(Max Conc. mM)
pka
15.04±0.29(Predicted)
form 
Liquid
color 
Colorless to light yellow
Odor
at 100.00 %. fruity nutty coconut
Odor Type
floral
optical activity
[α]/D -60±2°, neat
Water Solubility 
22mg/L at 20℃
JECFA Number
2031
LogP
5.5 at 25℃
CAS DataBase Reference
23089-26-1(CAS DataBase Reference)
EPA Substance Registry System
Levomenol (23089-26-1)
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Safety Information

RIDADR 
UN 3082 9 / PGIII
WGK Germany 
3
RTECS 
MJ9685000
HS Code 
2906195000
Toxicity
LD50 in male, female mice, rats (ml/kg): 15.2, 15.0, 14.9, 15.6 orally (Habersang)
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(-)-alpha-bisabolol Usage And Synthesis

Description

Bisabolol, or more formally (-)-alpha-bisabolol, also known as levomenol, is a natural monocyclic sesquiterpene alcohol. Alpha-bisabolol, an unsaturated monocyclic sesquiterpene alcohol, is known as one of the “most-used herbal constituents” worldwide. Various therapeutic and biological properties of α-bisabolol in preventing oxidative stress, inflammatory disorders, infections, neurodegenerative diseases, cancers, and metabolic disorders have been reported. It is a common additive in many PCPs, including dental care products, skin moisturisers, sunscreens, and make-up products, due to its multiple biological activities.

Uses

(-)-α-Bisabolol was used to investigate the leishmanicidal and cytotoxic activity of essential oil of Vanillosmopsis arborea.

Uses

Reference Standard in the analysis of herbal medicinal products

Definition

ChEBI: (-)-alpha-Bisabolol is a sesquiterpenoid.

benefits

The benefits of Bisabolol (or α-bisabolol) on the skin include soothing, anti-aging, maintaining skin firmness, improving skin pigmentation and moisturising the skin to reduce the appearance of fine lines.

General Description

(-)-α-Bisabolol is the major constituent of essential oil from leaves of Hymenocrater yazdianus.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

α-Bisabolol is active against primary acute leukemia cells, including BCR-ABL(+) acute lymphoblastic leukemias. It is the inhibitor of voltage-dependent Ca(2+) channels in tracheal smooth muscle preparations of rat. It also inhibits human and rat glioma cell growth and survival. It is a potential new therapeutic agent against leishmaniasis.

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