(-)-alpha-bisabolol
(-)-alpha-bisabolol Basic information
- Product Name:
- (-)-alpha-bisabolol
- Synonyms:
-
- A-(-)-BISABOLOL
- CAMILLOL
- BISABOLOL, A-(-)-
- BISABOLOL OXIDE A
- DRAGOSANTOL
- HYDAGEN B
- LEVOMENOL
- theta)]-thet
- CAS:
- 23089-26-1
- MF:
- C15H26O
- MW:
- 222.37
- EINECS:
- 245-423-3
- Product Categories:
-
- Miscellaneous Natural Products
- Mol File:
- 23089-26-1.mol
(-)-alpha-bisabolol Chemical Properties
- alpha
- D -55.7°; D20 -51.02° (Günther)
- Boiling point:
- bp12 153°
- Density
- d20 0.9211
- vapor pressure
- 0.015Pa at 20℃
- refractive index
- n20/D 1.496
- FEMA
- 4666 | ALPHA-BISABOLOL
- Flash point:
- 135 °C
- storage temp.
- -20°C
- solubility
- DMSO:100.0(Max Conc. mg/mL);449.7(Max Conc. mM)
- pka
- 15.04±0.29(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
- Odor
- at 100.00 %. fruity nutty coconut
- Odor Type
- floral
- optical activity
- [α]/D -60±2°, neat
- Water Solubility
- 22mg/L at 20℃
- JECFA Number
- 2031
- LogP
- 5.5 at 25℃
- CAS DataBase Reference
- 23089-26-1(CAS DataBase Reference)
- EPA Substance Registry System
- Levomenol (23089-26-1)
(-)-alpha-bisabolol Usage And Synthesis
Description
Bisabolol, or more formally (-)-alpha-bisabolol, also known as levomenol, is a natural monocyclic sesquiterpene alcohol. Alpha-bisabolol, an unsaturated monocyclic sesquiterpene alcohol, is known as one of the “most-used herbal constituents” worldwide. Various therapeutic and biological properties of α-bisabolol in preventing oxidative stress, inflammatory disorders, infections, neurodegenerative diseases, cancers, and metabolic disorders have been reported. It is a common additive in many PCPs, including dental care products, skin moisturisers, sunscreens, and make-up products, due to its multiple biological activities.
Uses
(-)-α-Bisabolol was used to investigate the leishmanicidal and cytotoxic activity of essential oil of Vanillosmopsis arborea.
Uses
Reference Standard in the analysis of herbal medicinal products
Definition
ChEBI: (-)-alpha-Bisabolol is a sesquiterpenoid.
benefits
The benefits of Bisabolol (or α-bisabolol) on the skin include soothing, anti-aging, maintaining skin firmness, improving skin pigmentation and moisturising the skin to reduce the appearance of fine lines.
General Description
(-)-α-Bisabolol is the major constituent of essential oil from leaves of Hymenocrater yazdianus.
Flammability and Explosibility
Not classified
Biochem/physiol Actions
α-Bisabolol is active against primary acute leukemia cells, including BCR-ABL(+) acute lymphoblastic leukemias. It is the inhibitor of voltage-dependent Ca(2+) channels in tracheal smooth muscle preparations of rat. It also inhibits human and rat glioma cell growth and survival. It is a potential new therapeutic agent against leishmaniasis.
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