TOFISOPAM Chemical Properties

Melting point:

155-159°C

Boiling point:

509.61°C (rough estimate)

Density 

1.2098 (rough estimate)

refractive index 

1.6500 (estimate)

solubility 

DMSO: ~14 mg/mL

form 

solid

pka

7.29±0.40(Predicted)

color 

white

λmax

310nm(MeOH)(lit.)

Merck 

14,9503

Stability:

Hygroscopic

Safety Information

Hazard Codes 

Xn,N

Risk Statements 

22-50

Safety Statements 

60-61

RIDADR 

UN 3077 9/PG 3

WGK Germany 

2

RTECS 

DE9540000

HS Code 

2933.99.8290

HazardClass 

6.1(b)

PackingGroup 

III

MSDS

• Language:English Provider:SigmaAldrich

TOFISOPAM Usage And Synthesis

Originator

Grandaxine,Ozothine,France,1975

Uses

Tofisopam is a reagent used in preparation of allosteric ligands for pharmacological dark receptors GPR68 and GPR65. An anticonvulsant.

Definition

ChEBI: Tofisopam is an organic molecular entity.

Manufacturing Process

A mixture of 38.6 g (0.1 mol) of 3,4,3',4'-tetramethoxy-6-(α-acetopropyl)- benzophenone, 5.5 g (0.11 mol) of 100% hydrazine hydrate or 3.52 g (0.11 mol) of hydrazine, and 500 ml of absolute ethanol is boiled for 5 hours. After adding 100 ml of benzene, 400 ml of solvent mixture is distilled off from the reaction mixture by slow boiling for 3 hours. After cooling for 8 hours, 19 g of 5H-2,3-benzodiazepine derivative are separated from the residue as small, white crystals. The melting point is 133°C to 136°C (after recrystallizing from absolute ethanol, 136°C)

Therapeutic Function

Tranquilizer

TOFISOPAM(22345-47-7)Related Product Information

• 3-[2-(3,4-dimethoxybenzoyl)-4,5-dimethoxyphenyl]pentan-2-one
• Toffee-related impurities
• (S)-Tofisopam
• (R)-Tofisopam
• ACETONE AZINE
• Acetophenone, 3-hydroxy-, hydrazone (6CI,7CI,8CI)
• TOFISOPAM