2,5-DICHLOROFLUOROBENZENE Chemical Properties

Melting point:

4 °C

Boiling point:

168 °C

Density 

1.383

refractive index 

1.5235-1.5255

Flash point:

65 °C

storage temp. 

Sealed in dry,Room Temperature

solubility 

Difficult to mix.

form 

clear liquid

color 

Colorless to Light yellow to Light orange

Specific Gravity

1.383

BRN 

2355590

CAS DataBase Reference

348-59-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

37/39-26

RIDADR 

1992

Hazard Note 

Irritant

PackingGroup 

III

HS Code 

29036990

MSDS

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2,5-DICHLOROFLUOROBENZENE Usage And Synthesis

Chemical Properties

CLEAR COLORLESS LIQUID

Uses

1,4-Dichloro-2-fluorobenzene is used as organic synthesis intermediates

Synthesis

General procedure for the synthesis of 2,5-dichlorofluorobenzene from 2,5-dichloroaniline: 1. Continuous diazotization step: material A (50 mL aqueous solution containing 2,5-dichloroaniline (100 mmol), fluoboric acid (120 mmol) and hydrochloric acid (180 mmol)) was pumped through a T-fitting into a reaction tube at a flow rate of 4 mL/min at 25°C with material B (50 mL aqueous solution containing sodium nitrite (105 mmol)), the mixture flowed through the outlet and collected in a cooling vessel. Vigorous stirring was maintained. The slurry was cooled to -5 °C and then diafiltrated. The solid was washed with methanol and subsequently dried under vacuum to give 2,5-dichlorobenzenediazonium tetrafluoroborate. 2. Continuous fluorination step: a slurry of 2,5-dichlorobenzenediazonium tetrafluoroborate prepared above in 300 mL of co-solvent was introduced continuously into a reaction tube at a flow rate of 4 mL/min. The mixture was kept at the set temperature for 1 min and subsequently cooled in the tandem tube. The collected liquid was washed with aqueous NaOH and water to give an almost colorless liquid of 2,5-dichlorofluorobenzene.

References

[1] Tetrahedron Letters, 2013, vol. 54, # 10, p. 1261 - 1263
[2] Journal of the American Chemical Society, 1959, vol. 81, p. 94,95, 97
[3] Journal of the American Chemical Society, 1953, vol. 75, p. 4590
[4] Acta Chimica Academiae Scientiarum Hungaricae, 1957, vol. 10, p. 227,229

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