2,4-Dimethoxyaniline Chemical Properties

Melting point:

33-36 °C (lit.)

Boiling point:

75-80 C

Density 

1.075 g/mL at 25 °C (lit.)

refractive index 

1.4640 (estimate)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

5.14±0.10(Predicted)

form 

Crystalline Solid

color 

Dark brown

Water Solubility 

7 g/L (20 ºC)

BRN 

638704

Stability:

Stability Stable, but sensitive to prolonged exposure to light. Incompatible with acids.

CAS DataBase Reference

2735-04-8(CAS DataBase Reference)

NIST Chemistry Reference

Benzenamine, 2,4-dimethoxy-(2735-04-8)

EPA Substance Registry System

2,4-Dimethoxyaniline (2735-04-8)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38-20/21/22

Safety Statements 

26-36-36/37/39-22

RIDADR 

2811

WGK Germany 

3

RTECS 

BX4200000

F 

8-10-23

TSCA 

Yes

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29214200

Hazardous Substances Data

2735-04-8(Hazardous Substances Data)

Toxicity

mouse,LD50,oral,1gm/kg (1000mg/kg),Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. Vol. NCI-E-C-72-3252, Pg. 1973,

MSDS

• Language:English Provider:2,4-Dimethoxyaniline
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2,4-Dimethoxyaniline Usage And Synthesis

Chemical Properties

black crystals

Uses

Various 2,4-dimethoxyphenylsemicarbazones were synthesized starting from 2,4-dimethoxyaniline via a phenylcarbamate intermediate. The hydrochloride of 2,4-dimethoxyaniline was prepared by intro- ducing hydrogen chloride gas into an etheral solution and washing the precipitate with absolute diethyl ether.

Synthesis Reference(s)

Tetrahedron Letters, 34, p. 2441, 1993 DOI: 10.1016/S0040-4039(00)60436-7

General Description

Black crystalline solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2,4-Dimethoxyaniline neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

ACUTE/CHRONIC HAZARDS: 2,4-Dimethoxyaniline is a local irritant.

2,4-Dimethoxyaniline(2735-04-8)Related Product Information

• Dimethyldimethoxysilane
• Phenetidine
• p-Anisidine
• m-Anisidine
• o-Anisidine
• 4-(Trifluoromethoxy)aniline
• 2,3-DIMETHOXYANILINE
• 3,4-DIMETHOXYANILINE
• 3,5-DIMETHOXYANILINE,5-AMINORESORCINOL DIMETHYL ETHER
• 2,5-DIMETHOXYANILINE
• 5-CHLORO-2,4-DIMETHOXYPHENYL ISOCYANATE
• 2,6-DIMETHOXY-3-NITROBENZOIC ACID
• Methyl 2-amino-3,4,5-trimethoxybenzoate
• BASIC YELLOW 11
• 2,4-DIMETHOXYPHENYL ISOCYANATE
• 2,4-Dimethoxy-1-nitrobenzene
• Methyl 2-nitro-3,4,5-trimethoxybenzoate
• N-(2-Hydroxynaphthoyl)-2,4-dimethoxy-5-chloroanilide