Basic information Safety Supplier Related

NOGALAMYCIN

Basic information Safety Supplier Related

NOGALAMYCIN Basic information

Product Name:
NOGALAMYCIN
Synonyms:
  • nsc-70845
  • NOGALAMYCIN, STREPTOMYCES NOGALATER
  • NOGALAMYCIN
  • AIDS031122
  • NOGALAMYCIN FROM STREPTOMYCES NOGALATER
  • Nogalamycin >=95%, from Streptomyces nogalater
  • antibiotic205t3
  • antibioticnsc70845
CAS:
1404-15-5
MF:
C39H49NO16
MW:
787.8
Product Categories:
  • Antibiotics
  • Antibiotics A to
  • Antibiotics by Application
  • Antibiotics N-SAntibiotics
  • Antineoplastic and Immunosuppressive AntibioticsAntibiotics
  • Inhibits an EnzymeAntibiotics
  • Interferes with DNA Synthesis
  • Mechanism of Action
Mol File:
1404-15-5.mol
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NOGALAMYCIN Chemical Properties

Melting point:
195-196° (dec)
alpha 
D25 +425° (c = 0.11 in CHCl3)
Boiling point:
658.61°C (rough estimate)
Density 
1.2095 (rough estimate)
refractive index 
1.7650 (estimate)
storage temp. 
2-8°C
pka
7.45 (60% ethanol)
color 
Orange-red solid from MeOH
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Safety Information

Hazard Codes 
T
Risk Statements 
45-46-61-20/21/22
Safety Statements 
53-22-36/37/39-45
WGK Germany 
3
RTECS 
RA4550000
Toxicity
LD50 in mice (mg/kg): 11.75 i.v., 4.79 i.p. (Hadidian)

MSDS

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NOGALAMYCIN Usage And Synthesis

Uses

Nogalamycin is an unusual anthracycline produced by Streptomyces nogalater var. nogalater, reported by researchers at Upjohn in 1965. Nogalamycin contains two saccharides. The neutral monosaccharide attaches to the D ring, similar to the aminoglycoside moieties of the doxorubicin class, while the second, basic saccharide attaches to the phenolic group on the A ring in the ortho position to form a unique family of hexacyclic anthracyclines. Nogalamycin is potent antibacterial and antitumor agent that interacts with DNA by intercalation.

Safety Profile

Poison by intravenous andintraperitoneal routes. Human mutation data reported. Anantibiotic. When heated to decomposition it emits toxicfumes of NOx.

NOGALAMYCINSupplier

BOC Sciences
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info@bocsci.com
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