NOGALAMYCIN
NOGALAMYCIN Basic information
- Product Name:
- NOGALAMYCIN
- Synonyms:
-
- nsc-70845
- NOGALAMYCIN, STREPTOMYCES NOGALATER
- NOGALAMYCIN
- AIDS031122
- NOGALAMYCIN FROM STREPTOMYCES NOGALATER
- Nogalamycin >=95%, from Streptomyces nogalater
- antibiotic205t3
- antibioticnsc70845
- CAS:
- 1404-15-5
- MF:
- C39H49NO16
- MW:
- 787.8
- Product Categories:
-
- Antibiotics
- Antibiotics A to
- Antibiotics by Application
- Antibiotics N-SAntibiotics
- Antineoplastic and Immunosuppressive AntibioticsAntibiotics
- Inhibits an EnzymeAntibiotics
- Interferes with DNA Synthesis
- Mechanism of Action
- Mol File:
- 1404-15-5.mol
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NOGALAMYCIN Chemical Properties
- Melting point:
- 195-196° (dec)
- alpha
- D25 +425° (c = 0.11 in CHCl3)
- Boiling point:
- 658.61°C (rough estimate)
- Density
- 1.2095 (rough estimate)
- refractive index
- 1.7650 (estimate)
- storage temp.
- 2-8°C
- pka
- 7.45 (60% ethanol)
- color
- Orange-red solid from MeOH
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Safety Information
- Hazard Codes
- T
- Risk Statements
- 45-46-61-20/21/22
- Safety Statements
- 53-22-36/37/39-45
- WGK Germany
- 3
- RTECS
- RA4550000
- Toxicity
- LD50 in mice (mg/kg): 11.75 i.v., 4.79 i.p. (Hadidian)
MSDS
- Language:English Provider:SigmaAldrich
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NOGALAMYCIN Usage And Synthesis
Uses
Nogalamycin is an unusual anthracycline produced by Streptomyces nogalater var. nogalater, reported by researchers at Upjohn in 1965. Nogalamycin contains two saccharides. The neutral monosaccharide attaches to the D ring, similar to the aminoglycoside moieties of the doxorubicin class, while the second, basic saccharide attaches to the phenolic group on the A ring in the ortho position to form a unique family of hexacyclic anthracyclines. Nogalamycin is potent antibacterial and antitumor agent that interacts with DNA by intercalation.
Safety Profile
Poison by intravenous andintraperitoneal routes. Human mutation data reported. Anantibiotic. When heated to decomposition it emits toxicfumes of NOx.
NOGALAMYCINSupplier
T&W GROUP
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- 021-61551611-
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Guangzhou Isun Pharmaceutical Co., Ltd
- Tel
- 020-39119399-
- isunpharm@qq.com
ChemStrong Scientific Co.,Ltd
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- 0755-66853366-
- sales@chem-strong.com
Sigma-Aldrich
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- 021-61415566- ;
- orderCN@merckgroup.com;orderCN@merckgroup.com
Lynnchem
- Tel
- 029-85992781-
- info@lynnchem.com
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