N,N-Diethyl-1,1,1-trimethylsilylamine Chemical Properties

Melting point:

-10°C

Boiling point:

125-126 °C(lit.)

Density 

0.767 g/mL at 25 °C(lit.)

vapor density 

>1 (vs air)

refractive index 

n20/D 1.411(lit.)

Flash point:

50 °F

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

Chloroform (Sparingly), DMSO (Slightly), Ethyl Acetate (Slightly)

pka

11.27±0.70(Predicted)

form 

clear liquid

Specific Gravity

0.763

color 

Colorless to Light yellow

Water Solubility 

decomposes

Sensitive 

Moisture Sensitive

Hydrolytic Sensitivity

7: reacts slowly with moisture/water

BRN 

635718

CAS DataBase Reference

996-50-9(CAS DataBase Reference)

NIST Chemistry Reference

N,N-Diethyl-1,1,1-trimethylsilylamine(996-50-9)

EPA Substance Registry System

Silanamine, N,N-diethyl-1,1,1-trimethyl- (996-50-9)

Safety Information

Hazard Codes 

F,C

Risk Statements 

11-34

Safety Statements 

26-36/37/39-45-24/25-16

RIDADR 

UN 2733 3/PG 2

WGK Germany 

3

F 

10-21

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29310095

MSDS

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N,N-Diethyl-1,1,1-trimethylsilylamine Usage And Synthesis

Chemical Properties

Colorless liquid

Uses

Trimethylsilyldiethylamine is a reagent used as an electrophilic trimethylsilyl source for cleavage of cyclic ethers, esters, oxazolidines, and cyclic acetals; also as a nucleophilic source of the diethylamino group, participating in the following synthesis reactions: Trimethylsilyl Group Transfer, Diethylamino Group Transfer, Trimethylsilyldiethylamine as Halosilane Equivalent, Silylation of Alcohols, Mild Generation of Phosphonochloridates, Silylation of Amines, Diethylamino Group Transfer, Conjugate Addition, Aminoalkylation of Aldehydes, Enamine and Silyl Enol Ether Preparation, Mediation of 1,4-Conjugate Additions, etc.

Uses

It is used to derivative polar organic compounds. N,N-Diethyl(trimethylsilyl)amine is a chemical reagent with wide application in organic chemistry and used in stereo specific addition reactions as well as in SN2 nucleophilic substitutions.

Definition

ChEBI: An N-silyl compound that is diethylamine in which the amino hydrogen is replaced by a trimethylsilyl group. N-(trimethylsilyl)diethylamine is a derivatisation agent used in gas chromatography/mass spectrometry applicat ons.

General Description

N,N-Diethyltrimethylsilylamine is a silylating agent used to derivatize polar organic compounds.

Purification Methods

Fractionate it through a 2ft vacuum-jacketed column containing Helipak packing with a reflux ratio of 10:1. [Sauer & Hasek J Am Chem Soc 68 241 1946, Langer et al. J Org Chem 23 50 1958, Rühlmann J Prakt Chem 9 315 1959, Beilstein 4 IV 4010.]

N,N-Diethyl-1,1,1-trimethylsilylamine(996-50-9)Related Product Information

• Iodotrimethylsilane
• Methyltris(methylethylketoxime)silane
• Diethyl malonate
• Diethyl carbonate
• Bromotrimethylsilane
• Dichloromethylvinylsilane
• (Trifluoromethyl)trimethylsilane
• Trimethylsilyl cyanide
• Mefenpyr-diethyl
• Diethyl phthalate
• TRIMETHYLSILANE
• 1-(TRIMETHYLSILYL)PYRROLIDINE
• N-PiperidinoTrimethylsilane
• 4-(Trimethylsilyl)morpholine
• 1-TRIMETHYLSILYL-2-PYRROLIDINONE
• Silicon
• Diethylamine
• Diethyl ether