3-AMINOMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties

Boiling point:

310.7±27.0 °C(Predicted)

Density 

1.078±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

pka

10.01±0.29(Predicted)

Appearance

White to off-white Solid

Safety Information

HS Code 

2934999090

3-AMINOMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER Usage And Synthesis

Uses

3-Aminomethyl-morpholine-4-tert-butyl carbonate can be used as a pharmaceutical synthesis intermediate.

Synthesis

A mixture of tert-butyl 3-[(2,2,2-trifluoroethanolylamino)-methyl]-morpholine-4-carboxylate (1.7 g) and potassium carbonate (3.77 g) in methanol (80 ml) and water (27 ml) was stirred for 4 hours at ambient temperature and then heated at 50??C for another 2 hours. The reaction mixture was concentrated to remove methanol, diluted with water and extracted with ethyl acetate (x3) and dichloromethane (x4). The combined extracts were dried and evaporated to give the title product tert-butyl 3-aminomethyl-morpholine-4-carbonate (0.97 g) as a yellow gel.

3-AMINOMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER(475106-18-4)Related Product Information

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