2-Methyl-4-nitropyridine Chemical Properties

Melting point:

32-34 °C

Boiling point:

241.5±20.0 °C(Predicted)

Density 

1.246±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform, Dichloromethane

form 

Solid

pka

2.04±0.10(Predicted)

color 

Yellow

CAS DataBase Reference

13508-96-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-41

Safety Statements 

26-39-24/25

HS Code 

29333990

2-Methyl-4-nitropyridine Usage And Synthesis

Chemical Properties

Yellow Solid

Uses

2-Methyl-4-nitropyridine (cas# 13508-96-8) is a compound useful in organic synthesis.

Synthesis

a) To a chloroform solution of 4-nitro-2-methylpyridine-N-oxide (11 g, 71.5 mmol) was slowly added a chloroform solution of phosphorus trichloride (PCl3, 33 mL, 0.37 mmol) at 0 °C and under argon protection. The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the mixture was poured into ice water and neutralized with ammonium hydroxide solution to neutral, followed by extraction with dichloromethane. The organic phases were combined and concentrated to give a yellow solid product. The solid was washed with a mixed ether-petroleum ether solvent to give 7.8 g of 2-methyl-4-nitropyridine in 79% yield with a melting point of 35 °C.

References

[1] Organic Letters, 2000, vol. 2, # 22, p. 3525 - 3526
[2] Chemical and Pharmaceutical Bulletin, 1998, vol. 46, # 10, p. 1656 - 1657
[3] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2446 - 2458
[4] Journal of Organic Chemistry, 1998, vol. 63, # 15, p. 5013 - 5030
[5] Synlett, 2009, # 18, p. 2927 - 2930

2-Methyl-4-nitropyridine(13508-96-8)Related Product Information

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