6-CHLORO-2-PICOLINIC ACID METHYL ESTER Chemical Properties

Melting point:

93-94°

Boiling point:

275.8±20.0 °C(Predicted)

Density 

1.294±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

-1.03±0.10(Predicted)

form 

Solid

color 

Pale yellow

Water Solubility 

Slightly soluble in water.

Safety Information

HazardClass 

IRRITANT

HS Code 

2933399990

6-CHLORO-2-PICOLINIC ACID METHYL ESTER Usage And Synthesis

Uses

Methyl 6-chloropyridine-2-carboxylate was coupled with 2-(trimethylstannyl)pyridine to afford methyl 2,2?-bipyridine-6-carboxylate.

Synthesis Reference(s)

Synthetic Communications, 14, p. 77, 1984 DOI: 10.1080/00397918408060867

Synthesis

6-Chloro-2-picolinic acid methyl ester is prepared by the reaction of methanol and 6-Chloropicolinic acid. The specific synthesis steps are as follows:
Add thionyl chloride (3.7 ml, 50.8 mmol) to a solution of 6-chloropicolinic acid (4.0 g, 25.4 mmol) in methanol (85 ml) at 0 C. Stir the resultant solution for 15 minutes at 0 C, 0.5 hours at room temperature, and 6 hours at 50 C. Concentrate the reaction in vacuo and dilute with CHCl3 (150ml). Wash the organic solution with saturated aqueous sodium bicarbonate (3 x 100 ml), and brine (1 x 100 ml) and dry with sodium sulfate. Filtration and concentration afford methyl 6-chloropicolinate 4.38 g (100 percent) as a white solid. 1H NMR (CDCl3): δ 8.05 (m, 1H), 7.73 (m, 1H), 7.42 (m, 1H), 3.95 (s, 3H).

6-CHLORO-2-PICOLINIC ACID METHYL ESTER(6636-55-1)Related Product Information

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