1-Naphthalenesulfonyl chloride Chemical Properties

Melting point:

64-67 °C (lit.)

Boiling point:

194-195 °C/13 mmHg (lit.)

Density 

1.3661 (estimate)

Flash point:

194-195°C/13mm

storage temp. 

Inert atmosphere,Room Temperature

solubility 

chloroform: soluble25mg/mL, clear to very slightly hazy, colorless to yellow

form 

powder to crystal

color 

White to Almost white

Water Solubility 

insoluble

Sensitive 

Moisture Sensitive

BRN 

2099333

CAS DataBase Reference

85-46-1(CAS DataBase Reference)

NIST Chemistry Reference

1-Naphthalenesulfonyl chlorine(85-46-1)

EPA Substance Registry System

1-Naphthalenesulfonyl chloride (85-46-1)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45-27

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

F 

10-21

Hazard Note 

Corrosive

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29049090

MSDS

• Language:English Provider:1-Naphthalenesulfonyl chloride
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1-Naphthalenesulfonyl chloride Usage And Synthesis

Chemical Properties

white to beige crystalline powder

Uses

1-Naphthalenesulfonyl chloride has been used in the preparation of 5?-O-naphthaleneiulfonyldeoxyuridine and 1-sulfonylindazole derivatives. The derivatives of this compound is used for quantitative metabolome analysis New set of isotope reagents, 12C4-, 12C213C2-, and 13C4-5-diethylamino-naphthalene-1-sulfonyl chloride (DensCl), in combination with liquid chromatography Fourier-transform ion cyclotron resonance mass spectrometry (LC-FTICR-MS) is used for improved analysis of the amine- and phenol-containing submetabolome.

General Description

1-Naphthalenesulfonyl chloride undergoes desulfitative carbonylative Stille cross-coupling reaction with tinglucal derivative.

Purification Methods

If the IR indicates the presence of OH, then treat it with an equal weight of PCl5 and heat it at ca 100o for 2hours, cool and pour onto ice + H2O, stir well and filter off the solid. Wash the solid with cold H2O and dry the solid in a vacuum desiccator over P2O5 + solid KOH. Extract the solid with pet ether (b 40-60o), filter off any insoluble solid and cool. Collect the crystalline sulfonyl chloride and recrystallise it from dry Et2O, pet ether or *C6H6/pet ether. If large quantities are available, then it can be distilled under high vacuum. [Fierz-Davaid & Weissenbach Helv Chim Acta 3 2312 1920.] The sulfonamide crystallises from EtOH (m 150.5o) or H2O (m 153o). [Beilstein 11 H 175, 11 II 93, 11 IV 383.]

1-Naphthalenesulfonyl chloride(85-46-1)Related Product Information

• Potassium chloride
• Sodium chloride
• Sulfuryl chloride
• N-Acetylsulfanilyl chloride
• 4-Nitrobenzenesulfonyl chloride
• Benzenesulfonyl chloride
• Acetyl chloride
• Calcium chloride
• Ammonium chloride
• Tosyl chloride
• Polyvinyl chloride
• Benzyl chloride
• Methanesulfonyl chloride
• Choline chloride
• Methylene Chloride
• Dansyl chloride
• 2-NAPHTHALENESULFONYL CHLORIDE,b-Naphthalenesulfonyl chloride
• 5-(Dibutylamino)-1-naphthalenesulfonyl chloride