COG-1410
COG-1410 Basic information
- Product Name:
- COG-1410
- Synonyms:
-
- COG-1410
- L-Leucinamide, N-acetyl-L-alanyl-L-seryl-2-methylalanyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-2-methylalanyl-L-lysyl-L-arginyl-L-leucyl-
- CAS:
- 878009-24-6
- MF:
- C64H121N21O14
- MW:
- 1408.78
- Mol File:
- 878009-24-6.mol
COG-1410 Chemical Properties
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C, protect from light, stored under nitrogen
- solubility
- DMSO : 100 mg/mL (70.98 mM; Need ultrasonic)
- form
- Solid
- pka
- 12.62±0.46(Predicted)
- color
- White to off-white
COG-1410 Usage And Synthesis
Uses
COG1410 is an apolipoprotein E-derived peptide and an apoptosis inhibitor. COG1410 exerts neuroprotective and antiinflammatory effects in a murine model of traumatic brain injury (TBI). COG1410 can be used for the research of neurological disease[1][2].
in vivo
COG1410 (0.3-0.6 mg/kg; a single i.v.) exhibits significant improvement on a short term test of vestibulomotor function and on a long term test of spatial learning and memory in mice[1].
?
COG1410 (0.8 mg/kg; a single i.v.) improves vestibulomotor function, decreases poststroke locomotor asymmetry, and decreases infarct volume of the ipsilateral hemisphere in rats[2].
| Animal Model: | Male C57Bl/6J mice (12-16 weeks) with TBI[1] |
| Dosage: | 0.3, 0.6 mg/kg |
| Administration: | A single i.v. by tail vein |
| Result: | Improved motor function on days 1-5 postinjury. Significantly improved cognitive impairment. Reduced the number of injured hippocampal neurons. Suppressed the microglial activation. |
References
[1] Laskowitz DT, et, al. COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury. J Neurotrauma. 2007 Jul;24(7):1093-107. DOI:10.1089/neu.2006.0192
[2] Tukhovskaya EA, et, al. COG1410, a novel apolipoprotein-E mimetic, improves functional and morphological recovery in a rat model of focal brain ischemia. J Neurosci Res. 2009 Feb 15;87(3):677-82. DOI:10.1002/jnr.21874
[3] Kuai L, et, al. Apolipoprotein E-Mimetic Peptide COG1410 Enhances Retinal Ganglion Cell Survival by Attenuating Inflammation and Apoptosis Following TONI. Front Neurosci. 2019 Sep 13;13:980. DOI:10.3389/fnins.2019.00980
COG-1410Supplier
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- 0510-85629785 18013409632
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