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Sarpogrelate

Basic information Safety Supplier Related

Sarpogrelate Basic information

Product Name:
Sarpogrelate
Synonyms:
  • (+/-)-2-(dimethylamino)-1-{(o-(m-methoxyphenethyl)phenoxy)methyl}ethyl hydrogen succinate
  • SARPOGRELATE
  • Butanedioic acid, mono[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester (9CI)
  • 4-[1-(dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]propan-2-yl]oxy-4-oxobutanoic acid
  • 4-[1-(dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]propan-2-yl]oxy-4-oxo-butanoic acid
  • 4-[1-(dimethylaminomethyl)-2-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]ethoxy]-4-keto-butyric acid
  • Sapogrelate
  • Butanedioic acid, 1-[2-(diMethylaMino)-1-[[2-[2-(3-Methoxyphenyl)ethyl]phenoxy]Methyl]ethyl] ester
CAS:
125926-17-2
MF:
C24H31NO6
MW:
429.51
Mol File:
125926-17-2.mol
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Sarpogrelate Chemical Properties

Boiling point:
585.9±50.0 °C(Predicted)
Density 
1.164±0.06 g/cm3(Predicted)
pka
4.25±0.17(Predicted)
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Sarpogrelate Usage And Synthesis

Uses

Sarpogrelate (MCI-9042) is a new, specific orally active 5-HT2 receptor antagonist, Sarpogrelate increases platelet aggregation and has hemostasis effect, and can be used for the research of Buerger’s disease[1].

Definition

ChEBI: Sarpogrelate is a stilbenoid and a hemisuccinate.

IC 50

5-HT2 Receptor

References

[1] A Rydzewski, et al. The effect of a 5HT2 receptor antagonist sarpogrelate (MCI-9042) treatment on platelet function in Buerger's disease. Thromb Res. 1996 Dec 15;84(6):445-52. DOI:10.1016/s0049-3848(96)00212-5

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