1-(2-Furoyl)piperazine Chemical Properties

Melting point:

67-70 °C(lit.)

Boiling point:

137-140°C 0,1mm

Density 

1.1819 (rough estimate)

refractive index 

1.5373 (estimate)

Flash point:

>230 °F

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

Chloroform, Methanol (Slightly)

pka

8.37±0.10(Predicted)

color 

White to Pale Yellow

Sensitive 

Hygroscopic

BRN 

880196

Stability:

Very Hygroscopic

CAS DataBase Reference

40172-95-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-24/25

WGK Germany 

3

F 

10-34

HazardClass 

IRRITANT

HS Code 

29339900

MSDS

• Language:English Provider:1-(2-Furoyl)piperazine
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1-(2-Furoyl)piperazine Usage And Synthesis

Chemical Properties

white to light yellow solid

Uses

2-Furanyl-1-piperazinylmethanone (Terazosin EP Impurity L) was utilized in the fragment-based design of symmetrical bis-benzimidazole as inhibitors of R67 dihydrofolate reductase.

Uses

1-(2-Furoyl)piperazine may be used to synthesize:

• 2-[4-(2-furoyl) piperazin-1-yl]-4-amino-6-benzyloxy-7-methoxyquinazoline hydrochloride monohydrate
• 2-[4-(2-furoyl)piperazin-1-yl]-4-amino-7-benzyloxy-6-methoxyquinazoline hydrochloride monohydrate
• 4-amino-2-[4-(2-furoyl)piperazin-1-yl]-quinazoline hydrochloride
• 6,7-dimethoxy-2-[4-(2-furoyl)-piperazin-1-yl]quinazoline-4-one hydrate
• 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(2-furoyl)-piperazine hydrogen oxalate
• 1-(3,4-dichlorobenzyl)-4-(2-furoyl)-piperazine hydrogen oxalate
• 4-(9-fluorenyl)-1-(2-furoyl)piperazine
• 2-[4-(2-furoyl)piperazin-1-yl]-benzimidazole hydrochloride hydrate

Uses

2-Furanyl-1-piperazinylmethanone was utilized in the fragment-based design of symmetrical bis-benzimidazole as inhibitors of R67 dihydrofolate reductase.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 20, p. 146, 1977 DOI: 10.1021/jm00211a031

1-(2-Furoyl)piperazine(40172-95-0)Related Product Information

• N-Aminoethylpiperazine
• 2-Ethylhexyl ferulate
• Piperazine
• Piperacillin
• 1-(Tetrahydro-2-Furoyl)Piperazine,TerazosinHcl,,1-(TETRAHYDRO-2-FUROYL)PIPERAZINE,N-(TETRAHYDRO-2-FUROYL)-PIPERAZINE
• 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazine monohydrochloride
• Terazosin impurity
• 2-Piperazine-4-amino-6,7-dimethoxyquinazoline
• (R)-Terazosin
• 2,2'-(1,4-Piperazinediyl)bis[6,7-diMethoxy-4-quinazolinaMine]
• 1-[4-(4-AMino-6,7-diMethoxy-2-quinazolinyl)-1-piperazinyl]-5-hydroxy-1-pentanone
• 6,7-DiMethoxy-2-(4-(tetrahydrofuran-2-carbonyl)piperazin-1-yl)quinazolin-4(1H)-one
• Terazosin EP IMpurity D
• [4-(4-AMino-7-hydroxy-6-Methoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)Methanone
• NSC 351869
• [4-(4-AMino-6,7-diMethoxy-2-quinazolinyl)-1-piperazinyl][(5S)-tetrahydro-5-Methyl-2-furanyl]Methanone
• Terazosin hydrochloride dihydrate
• Terazosin IMpurity J