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Propiverine hydrochloride

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Propiverine hydrochloride Basic information

Product Name:
Propiverine hydrochloride
Synonyms:
  • (1-methyl-3,4,5,6-tetrahydro-2h-pyridin-4-yl) 2,2-diphenyl-2-propoxy-acetate chloride
  • 1-methyl-4-piperidyl diphenylpropoxyacetate hydrochloride
  • PROPIVERINE HCL
  • propiverine hydrochloride
  • PROPIVERINE HYDROCHLORRIDE
  • aceticacid,diphenylpropoxy-,1-methyl-4-piperidylester,hydrochloride
  • alpha,alpha-diphenyl-alpha-n-propoxyaceticacid1-methylpiperidyl-4-esterhyd
  • alpha-phenyl-alpha-propoxy-benzeneaceticaci1-methyl-4-piperidinylester
CAS:
54556-98-8
MF:
C23H30ClNO3
MW:
403.94
Product Categories:
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Aromatics
  • Heterocycles
Mol File:
54556-98-8.mol
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Propiverine hydrochloride Chemical Properties

Melting point:
224-226°C
storage temp. 
2-8°C
solubility 
H2O: soluble5mg/mL, clear (warmed)
form 
powder
color 
white to beige
CAS DataBase Reference
54556-98-8(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
37/38-41
Safety Statements 
26-39
WGK Germany 
3
RTECS 
AH3297000
Toxicity
LD50 in male, female mice, male, female rats (mg/kg): 36, 36, 22, 25 i.v.; 223, 283, 1632, 1411 s.c.; 410, 323, 1000, 1092 orally (Yamashita)
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Propiverine hydrochloride Usage And Synthesis

Description

Propiverine hydrochloride is a new urological agent developed for pollakuria and aconuresis. It appears to exhibit anticholinergic properties and in animal experiments inhibited KCl induced contractions in the bladder and ileum.

Chemical Properties

Off-White Solid

Originator

Apogepha (Germany)

Uses

Propiverine is used in treatment of urinary incontinence. Propiverine is an anticholinergic.

Definition

ChEBI: Propiverine hydrochloride is a diarylmethane.

brand name

Mictonorm; Mictonetten

General Description

Propiverine hydrochloride drug is a tertiary amine with spasmolytic and analgesic properties. This drug exerts neurotropic and musculotropic effects on the urinary bladder and smooth muscles. Propiverine hydrochloride has a half-life of 20 hours.

Biochem/physiol Actions

Propiverine is an antimuscarinic drug used for the treatment of overactive blaqdder and urinary incontinence. Propiverine and/or its metabolites also have calcium channel blocking properties in addition to antimuscarinic activity, which may contribute to the clinical activity.

Clinical Use


Treatment of urinary frequency, urgency and incontinence
Neurogenic bladder instability

Drug interactions

Potentially hazardous interactions with other drugs
Anti-arrhythmics: increased risk of antimuscarinic side effects with disopyramide.

Metabolism

Propiverine is extensively metabolised by intestinal and hepatic enzymes. Four metabolites were identified in urine; two of them are pharmacologically active and may contribute to the therapeutic efficacy.
Propiverine and its metabolites are excreted in the urine, bile and faeces.

Propiverine hydrochlorideSupplier

Kangmei Pharmaceutical Co., Ltd. Gold
Tel
0663-2917777
Email
kangmeixg@kangmei.com.cn
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Email
sales@boylechem.com
J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Email
isenchem@163.com
LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com