Propiverine hydrochloride
Propiverine hydrochloride Basic information
- Product Name:
- Propiverine hydrochloride
- Synonyms:
-
- (1-methyl-3,4,5,6-tetrahydro-2h-pyridin-4-yl) 2,2-diphenyl-2-propoxy-acetate chloride
- 1-methyl-4-piperidyl diphenylpropoxyacetate hydrochloride
- PROPIVERINE HCL
- propiverine hydrochloride
- PROPIVERINE HYDROCHLORRIDE
- aceticacid,diphenylpropoxy-,1-methyl-4-piperidylester,hydrochloride
- alpha,alpha-diphenyl-alpha-n-propoxyaceticacid1-methylpiperidyl-4-esterhyd
- alpha-phenyl-alpha-propoxy-benzeneaceticaci1-methyl-4-piperidinylester
- CAS:
- 54556-98-8
- MF:
- C23H30ClNO3
- MW:
- 403.94
- Product Categories:
-
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Aromatics
- Heterocycles
- Mol File:
- 54556-98-8.mol
Propiverine hydrochloride Chemical Properties
- Melting point:
- 224-226°C
- storage temp.
- 2-8°C
- solubility
- H2O: soluble5mg/mL, clear (warmed)
- form
- powder
- color
- white to beige
- CAS DataBase Reference
- 54556-98-8(CAS DataBase Reference)
Propiverine hydrochloride Usage And Synthesis
Description
Propiverine hydrochloride is a new urological agent developed for pollakuria and aconuresis. It appears to exhibit anticholinergic properties and in animal experiments inhibited KCl induced contractions in the bladder and ileum.
Chemical Properties
Off-White Solid
Originator
Apogepha (Germany)
Uses
Propiverine is used in treatment of urinary incontinence. Propiverine is an anticholinergic.
Definition
ChEBI: Propiverine hydrochloride is a diarylmethane.
brand name
Mictonorm; Mictonetten
General Description
Propiverine hydrochloride drug is a tertiary amine with spasmolytic and analgesic properties. This drug exerts neurotropic and musculotropic effects on the urinary bladder and smooth muscles. Propiverine hydrochloride has a half-life of 20 hours.
Biochem/physiol Actions
Propiverine is an antimuscarinic drug used for the treatment of overactive blaqdder and urinary incontinence. Propiverine and/or its metabolites also have calcium channel blocking properties in addition to antimuscarinic activity, which may contribute to the clinical activity.
Clinical Use
Treatment of urinary frequency, urgency and
incontinence
Neurogenic bladder instability
Drug interactions
Potentially hazardous interactions with other drugs
Anti-arrhythmics: increased risk of antimuscarinic
side effects with disopyramide.
Metabolism
Propiverine is extensively metabolised by intestinal and
hepatic enzymes. Four metabolites were identified in
urine; two of them are pharmacologically active and may
contribute to the therapeutic efficacy.
Propiverine and its metabolites are excreted in the urine,
bile and faeces.
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