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Tritiozine

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Tritiozine Basic information

Product Name:
Tritiozine
Synonyms:
  • Tritiozine
  • trithiozine
  • Sulmetozine
  • 4-(3,4,5-Trimethoxythiobenzoyl)morpholine
  • 4-[Thioxo(3,4,5-trimethoxyphenyl)methyl]morpholine
  • ISF-2001
  • morpholin-4-yl-(3,4,5-trimethoxyphenyl)methanethione
  • morpholino-(3,4,5-trimethoxyphenyl)methanethione
CAS:
35619-65-9
MF:
C14H19NO4S
MW:
297.37
EINECS:
2526454
Mol File:
35619-65-9.mol
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Tritiozine Chemical Properties

Melting point:
141-143°
Boiling point:
420.8±55.0 °C(Predicted)
Density 
1.2461 (rough estimate)
refractive index 
1.7500 (estimate)
pka
0.88±0.20(Predicted)
form 
Solid
color 
Off-white to light yellow
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Safety Information

Toxicity
LD50 i.p. in mice: 2000 mg/kg (Pifferi, 1973)
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Tritiozine Usage And Synthesis

Uses

Trithiozine is an orally active antisecretory and antiulcer agent. Trithiozine can be used for the research of peptic ulcer disease and hypersecretory disorders[1].

Definition

ChEBI: Tritiozine is a member of methoxybenzenes.

in vivo

Trithiozine (T) (i. p., oral, i. v.; 50 mg/kg, 200 mg/kg) shows a considerable antisecretory and antiulcer activity on different experimental models in the rats and dogs[1].

Animal Model:female Sprague-Dawley rats and male beagle dogs[1]
Dosage:50 mg/kg (rats); 200 mg/kg or 50 mg/kg (dogs)
Administration:i. p., single (rats); oral, single or i. v. (dogs)
Result:Showed an apparent plasma half-life of about 2.5 h in rats and 1 h in dogs and rapidly metabolized yielding two metabolites and two conjugates.

References

[1] G. M. Pacifici, et al. Pharmacokinetics and biotransformation, in rats and dogs, of trithiozine, a new antisecretory drug. , 1(3), 141–147. doi:10.1007/bf03189268.

TritiozineSupplier

Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
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Zhuhai Aobokai Biomedical Technology Co., Ltd.
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TargetMol Chemicals Inc.
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Shaanxi Dideu Medichem Co. Ltd
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+86-029-89586680 +86-18192503167
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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