Thioproperazine Chemical Properties

Melting point:

140°

Boiling point:

612.2±65.0 °C(Predicted)

Density 

1.1476 (rough estimate)

refractive index 

1.6200 (estimate)

storage temp. 

Sealed in dry,Room Temperature

form 

Solid

pka

7.65±0.10(Predicted)

color 

Light yellow to yellow

NIST Chemistry Reference

Thioproperazine(316-81-4)

Safety Information

Toxicity

LD50 oral in mouse: 830mg/kg

MSDS

• Language:English Provider:N,N-Dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide

Thioproperazine Usage And Synthesis

Originator

Majeptil,Specia,France,1960

Definition

ChEBI: A phenothiazine derivative in which the phenothiazine tricycle has a dimethylaminosulfonyl substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at N-10.

Manufacturing Process

A solution of 3-dimethylsulfamoylphenthiazine (5 g) in anhydrous xylene (100 cc) is heated under reflux for 1 hour with sodamide (0.67 g). 3-(4-methyl-1- piperazinyl)-1-chloropropane (3.2 g) in solution in anhydrous xylene (20 cc) is added and the mixture heated under reflux for 5 hours. After treatment of the reaction products, a crude oily base (2.5 g) is obtained after treatment. By the addition of a solution of fumaric acid in ethanol to an ethanolic solution of the base, 3-dimethylsulfamoyl-10-(3-41-methyl-11-piperazinylpropyl)- phenthiazinediacid fumarate (2.6 g) is obtained, melting point 182°C. The base recrystallized from ethyl acetate melts at about 140°C.

Therapeutic Function

Neuroleptic, Antiemetic

Thioproperazine(316-81-4)Related Product Information

• N,N-Dimethylformamide
• Cyclopropanesulfonamide
• Phenothiazine
• p-Toluenesulfonamide
• Dimethyl ether
• Propyl gallate
• Imipramine hydrochloride
• Dimethyl sulfide
• 4,4'-Diaminodiphenylsulfone
• Benzenesulfonamide
• Dimethyl fumarate
• Terazosin hydrochloride
• Thioridazine
• Dimethyl sulfoxide
• ETHANE
• Propyl butyrate
• DIOXOPROMETHAZINE HCL
• CHLORPROPAMIDE