4-O-(Carboxymethyl)rifamycin Chemical Properties

Melting point:

300° (dec 160-164°)

alpha 

D20 -11° (methanol)

Boiling point:

730.16°C (rough estimate)

Density 

1.2421 (rough estimate)

refractive index 

1.5350 (estimate)

solubility 

DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Sonicated)

pka

2.69±0.10(Predicted)

BRN 

604953

Stability:

Unstable in solution

Safety Information

Toxicity

LD50 in mice (mg/kg): 2040 i.v., >3000 i.p., s.c., and orally (Sensi, 1964)

4-O-(Carboxymethyl)rifamycin Usage And Synthesis

Uses

Rifamycin B (Rifaximin EP Impurity B) is a Rifamycin (R508200) derivative as antibacterial agent.

Uses

A Rifamycin (R508200) derivative as antibacterial agent.

Definition

ChEBI: Rifamycin B is a carboxylic acid, an acetate ester, an organic heterotetracyclic compound and a member of rifamycins. It is a conjugate acid of a rifamycin B(2-).

Purification Methods

Rifamycin B forms yellow needles from *C6H6. Its solubilities are: H2O (0,027%), MeOH (2.62%) and EtOH (0.44%). It has UV max at 223, 304 and 245nm (A 1cm 555, 275 and 220). [Oppolzer & Prelog Helv Chim Acta 56 2287 1973, Oppolzer et al. Experientia 20 336 1964, X-ray: Brufani et al. Experientia 20 339 1964.]

4-O-(Carboxymethyl)rifamycin(13929-35-6)Related Product Information

• Rifamycin S
• Rifamycin O
• 25-deacetoxy-25-hydroxyrifamycin S
• 4-HYDROXYPHENOXYACETIC ACID
• 2-METHOXY-1-NAPHTHALDEHYDE
• 3,3-Dimethoxybutan-2-one
• 6-Hydroxy-2,3-dihydrobenzo[b]furan-3-one
• 1,4-Dihydroxynaphthalene
• 1,3-DIMETHYLNAPHTHALENE
• 1,7-DIMETHOXYNAPHTHALENE
• Rifampicin
• 1,6-Dihydroxynaphthalene
• 4-O-(Carboxymethyl)rifamycin
• 2-Naphthaleneethanol
• 2-HYDROXY-1-NAPHTHALDEHYDE
• 6-METHOXY-1-NAPHTHOL
• 4-METHOXY-1-NAPHTHOL
• PHENYLGLYOXAL MONOHYDRATE