colchiceine
colchiceine Basic information
- Product Name:
- colchiceine
- Synonyms:
-
- Colchicine EP Impurity F
- (S)-7-Acetylamino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one
- colchiceine
- N-[(7S)-5,6,7,9-Tetrahydro-10-hydroxy-1,2,3,-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide
- NSC 3341
- O10-Demethylcolchicine
- NSC 33411
- Colchicine Impurity 6（Colchicine EP Impurity F）
- CAS:
- 477-27-0
- MF:
- C21H23NO6
- MW:
- 385.41
- EINECS:
- 207-512-5
- Product Categories:
-
- Various Metabolites and Impurities
- Intermediates & Fine Chemicals
- Metabolites & Impurities
- Pharmaceuticals
- Mol File:
- 477-27-0.mol
colchiceine Chemical Properties
- Melting point:
- 172-1740C
- alpha
- D25 -255.1° (c = 1 in chloroform)
- Boiling point:
- 511.86°C (rough estimate)
- Density
- 1.2400
- refractive index
- 1.5614 (estimate)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 7.59±0.40(Predicted)
- form
- Solid
- color
- Off-White to Pale Yellow
colchiceine Usage And Synthesis
Description
Colchicine is obtained by extracting the seeds and/or corm of Colchicum autumnale Linn′e. Colchicine is a specific drug for the treatment of gouty arthritis. It is especially useful in acute attacks but also is used prophylactically in conjunction with other drugs, such as allopurinol or phenylbutazone. The drug is believed to act by disrupting microtubular assembly in inflammatory cells, thereby impairing both their locomotion and their membrane function, including phagocytosis and the release of inflammatory mediators. The alkaloid is extremely toxic and must be used with care. Gastrointestinal adverse effects include nausea, vomiting, and diarrhea. Blood disorders, including agranulocytosis and aplastic anemia, sometimes are seen after prolonged administration of this drug.
Chemical Properties
Off- White to Pale Yellow Solid
Uses
A metabolite of Colchicine
Definition
ChEBI: Colchiceine is a cyclic ketone.
Trade name
Colchicina (Smith Kline, Brazil), Colchicine (Various, USA), ColchicumDispert (Solvay, Poland), Colabid (Major, USA).
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colchiceine(477-27-0)Related Product Information
- Cinnamtannin D1
- ProtopluMericin A
- Colchicine
- [epicatechin-(4beta->8)]5-epicatechin
- colchiceine
- COLCHICOSIDE
- COLCHICINE, [RING C, METHOXY-14C]
- COLCHICINE-D6
- COLCHICINE-D3
- Colchicine, N-methyl-
- COLCHICINE METHANETHIOSULFONATE
- COLCHICEINE-D3
- N-TRIFLUOROACETYL DEACETYLCOLCHICINE
- N-TRIFLUOROACETYL-N-METHYL-DEACETYLCOLCHICINE
- N-TRIFLUOROACETYL DEACETYLCOLCHICEINE
- N-TRIFLUOROACETYL-N-METHYL-DEACETYLCOLCHICEINE
- COLCHICINE, [RING C, METHOXY-3H]
- COLCHICINE SALICYLATED