Spirapril hydrochloride Chemical Properties

Melting point:

192-1940C (dec.)

alpha 

D26 -11.2° (c = 0.4 in ethanol)

storage temp. 

-20°C Freezer

solubility 

Very slightly soluble in water, soluble in methanol, slightly soluble in acetonitrile, practically insoluble in methylene chloride.

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

Spirapril hydrochloride Usage And Synthesis

Description

Spirapril hydrochloride is a new ACE inhibitor introduced in Finland for the treatment of hypertension. Spirapril is orally active and rapidly absorbed and converted to the active diacid spiraprilat which produces a reduction in blood pressure similar to that seen with enalapril and captopril. Spirapril has been reported to be well tolerated and exhibits an apparently lower incidence of cough compared with other ACE inhibitors. The elimination of spirapril occurs via both renal and hepatic routes so that no dosage adjustment is required for patients with renal impairment. In patients with severe congestive heart failure, spirapril has demonstrated beneficial hemodynamic effects with a duration of action >24 hours.

Chemical Properties

White Solid

Originator

Schering-Plough (U.S.A.)

Uses

Angiotensin-converting enzyme (ACE) inhibior. Antihypertensive.

brand name

Renormax (Schering);Renpress.

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