8-Hydroxyisoquinoline Chemical Properties

Melting point:

213 °C

Boiling point:

332.1±15.0 °C(Predicted)

Density 

1.260±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

form 

claggy powder

pka

8.40±0.10(Predicted)

color 

Light brown

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

22

Hazard Note 

Irritant

HS Code 

2933499090

8-Hydroxyisoquinoline Usage And Synthesis

Synthesis

2-Methoxybenzaldehyde and 2,2-dimethoxyethylamine react in benzene to form an aldehyde-amine condensation reaction, which then reacts with ethyl chloroformate and trimethyl phosphite to generate 8-methoxyisoquinolin-4(3H)-one intermediate Chemicalbook. The intermediate is refluxed and dehydrated with titanium tetrachloride in dichloromethane to generate the intermediate 8-methoxyisoquinoline, which is then demethylated with boron tribromide in dichloromethane at low temperature to generate Isoquinolin-8-ol (8-Hydroxyisoquinoline).

8-Hydroxyisoquinoline(3482-14-2)Related Product Information

• Isoquinoline
• Glycolic acid
• 4-Hydroxybenzaldehyde
• 8-Hydroxyquinoline
• 10-Hydroxycamptothecin
• Hydroxyapatite
• Hydroxy silicone oil
• methyl 8-hydroxyquinoline-4-carboxylate
• 8-Hydroxy-isoquinoline-5-carboxylic acid
• 8-hydroxyquinoline-4-carboxylic acid
• 2-chloroquinolin-8-ol
• 8-Quinolinecarbonitrile
• 5-Hydroxyisoquinoline
• 5,6,7,8-TETRAHYDROISOQUINOLINE
• BERBERINE SULFATE TRIHYDRATE
• 2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol
• Coptisine chloride
• BERBERINE ACID SULFATE