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Isoliensinine

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Isoliensinine Basic information

Product Name:
Isoliensinine
Synonyms:
  • Isoliensinine
  • (+)-Isoliensinin
  • (1R)-1,2,3,4-Tetrahydro-1-[[4-hydroxy-3-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]phenyl]methyl]-6-methoxy-2-methyl-7-isoquinolinol
  • (1R)-1-[[4-hydroxy-3-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenyl]methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol
  • 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[[4-hydroxy-3-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]phenyl]methyl]-6-methoxy-2-methyl-, (1R)-
  • Isoliensinine USP/EP/BP
  • (+)-Isoliensinine
  • (1R)-1-(4-hydroxy-3-{[(1R)-6-methoxy-1-(4-methoxybenzyl)-2-m...
CAS:
6817-41-0
MF:
C37H42N2O6
MW:
610.74
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
6817-41-0.mol
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Isoliensinine Chemical Properties

Melting point:
69-71℃
Boiling point:
723.1±60.0 °C(Predicted)
Density 
1.218
storage temp. 
2-8°C(protect from light)
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
powder
pka
9.28±0.45(Predicted)
color 
White
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Isoliensinine Usage And Synthesis

Description

Tomita and his co-workers have obtained this bisisoquinoline alkaloid from the embryo of the seeds of Nelumbo nucifera Gaertn. The base has [α]29D + 49.3° (Me2CO) and - 43.3° (CHC13 ). The hydrochloride tetrahydrate forms colourless crystals, m.p. l85-6°C (dry); the perchlorate monohydrate has m.p. 200-3°C (dry); [α]22D - 70° (Me2CO) and the styphnate of the O,O-dimethyl ether, also crystalline, has m.p. l33-5°C; [α]27D - 81.5° (Me2CO). Three methoxyl, two hydroxyl and two methylimino groups are present.

Uses

(+)-Isoliensinine is an alkaloid which displays activation of AMP-activated kinase and regulation of PPARγ receptors.

Definition

ChEBI: Isoliensinine is a member of isoquinolines.

References

Tomita et aI., Tetrahedron Lett., 2637,3374 (1964)

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