Topotecan(Tpt)
Topotecan(Tpt) Basic information
- Product Name:
- Topotecan(Tpt)
- Synonyms:
-
- Ro 24-7429
- Tat,anti-inflammatory,antifibrotic,inhibit,Ro247429,Ro24-7429,RUNX1,Inhibitor,Apoptosis,Human immunodeficiency virus,HIV-1,anti-HIV,Ro24 7429,HIV
- Ro24-7429, 10 mM in DMSO
- CAS:
- 139339-45-0
- MF:
- C14H13ClN4
- MW:
- 272.73
- Product Categories:
-
- APIS
- Mol File:
- 139339-45-0.mol
Topotecan(Tpt) Chemical Properties
- storage temp.
- Store at -20°C
- form
- Solid
- color
- White to yellow
Topotecan(Tpt) Usage And Synthesis
Uses
Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects[1][2].
Definition
ChEBI: 7-chloro-N-methyl-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepin-2-amine is a benzodiazepine.
in vivo
Ro24-7429 (17.5-70 mg/kg; i.p.; daily; for 14 or 21 days) treatment robustly ameliorates lung fibrosis and inflammation in the Bleomycin-induced pulmonary fibrosis (PF) mouse model. Ro24-7429 curbs expression of fibrosis markers in injured mouse lungs[2].
| Animal Model: | C57BL/6J male and female mice (aged 6 to 8 weeks) induced by Bleomycin[2] |
| Dosage: | 17.5 mg/kg, 35 mg/kg, and 70 mg/kg |
| Administration: | i.p.; daily; for 14 or 21 days |
| Result: | Ameliorated lung fibrosis and inflammation in the Bleomycin-induced PF mouse model. |
IC 50
HIV-1
References
[1] A H Patki, et al. HIV-1 Tat protein and its inhibitor Ro 24-7429 inhibit lymphocyte proliferation and induce apoptosis in peripheral blood mononuclear cells from healthy donors. Cell Immunol. 1996 Apr 10;169(1):40-6. DOI:10.1006/cimm.1996.0088
[2] Michael O'Hare, et al. Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators. Am J Pathol. 2021 Jul;191(7):1193-1208. DOI:10.1016/j.ajpath.2021.04.006
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