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Sinapine

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Sinapine Basic information

Product Name:
Sinapine
Synonyms:
  • Ethanaminium, 2-((3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl)o xy)-N,N,N-trimethyl-
  • 2-[[3-(4-Hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl]oxy]-N,N,N-trimethylethanaminium
  • Sinapic acid choline ester
  • 2-((3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl)o xy)-N,N,N-trimethyl-2-[[3-(4-Hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl]oxy]-N,N,N-trimethylethanaminium
  • 2-[[3-(4-Hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propen-1-yl]oxy]-N,N,N-trimethylethanaminium
  • Ethanaminium,2-[[3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propen-1-yl]oxy]-N,N,N-trimethyl-
  • Sinapin
  • 2-((3-(4-Hydroxy-3,5-dimethoxyphenyl)acryloyl)oxy)-N,N,N-trimethylethan-1-aminium
CAS:
18696-26-9
MF:
[C16H24NO5]+.
MW:
0
Mol File:
18696-26-9.mol
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Sinapine Chemical Properties

Melting point:
178℃
storage temp. 
4°C, away from moisture and light
solubility 
DMSO : 250 mg/mL (805.52 mM; Need ultrasonic)
form 
Powder
color 
Off-white to yellow
InChI
InChI=1S/C16H23NO5/c1-17(2,3)8-9-22-15(18)7-6-12-10-13(20-4)16(19)14(11-12)21-5/h6-7,10-11H,8-9H2,1-5H3/p+1
InChIKey
HUJXHFRXWWGYQH-UHFFFAOYSA-O
SMILES
C1(O)=C(OC)C=C(C=C1OC)/C=C/C(OCC[N+](C)(C)C)=O
LogP
-3.370 (est)
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Sinapine Usage And Synthesis

Uses

Sinapine is an alkaloid isolated from seeds of the cruciferous species. Sinapine exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease[1][2][3][4].

Definition

ChEBI: An acylcholine in which the acyl group specified is sinapoyl.

in vivo

Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota[2].

IC 50

AChE

References

[1] Boulghobra D, et, al. Sinapine, but not sinapic acid, counteracts mitochondrial oxidative stress in cardiomyocytes. Redox Biol. 2020 Jul;34:101554. DOI:10.1016/j.redox.2020.101554
[2] Li Y, et, al. Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota. Food Funct. 2019 Jun 19;10(6):3637-3649. DOI:10.1039/c9fo00195f
[3] Guo Y, et al. Sinapine as an active compound for inhibiting the proliferation of Caco-2 cells via downregulation of P-glycoprotein. Food Chem Toxicol. 2014 May;67:187-92. DOI:10.1016/j.fct.2014.02.035
[4] Yates K, et, al. Determination of sinapine in rapeseed pomace extract: Its antioxidant and acetylcholinesterase inhibition properties. Food Chem. 2019 Mar 15;276:768-775. DOI:10.1016/j.foodchem.2018.10.045

SinapineSupplier

Chengdu Nakeli Biotechnology Co., Ltd. Gold
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028-61983833 19138982515
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Chengdu Biopurify Phytochemicals Ltd.
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+86-028-82633397 18982077548
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Chengdu Climax Biotech Co., Ltd.
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028-83311324 1278112614
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Shanghai Tauto Biotech Co., Ltd.
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021-51320588
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Chengdu HuaXia Chemical Reagent Co. Ltd
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400-1166-196 13458535857
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cdhxsj@163.com