2-BROMO-5-CYANO-4-PICOLINE Chemical Properties

Boiling point:

288℃

Density 

1.61

Flash point:

128℃

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-2.00±0.18(Predicted)

Appearance

White to off-white Solid

InChI

InChI=1S/C7H5BrN2/c1-5-2-7(8)10-4-6(5)3-9/h2,4H,1H3

InChIKey

DHUDYHHQMIRPHS-UHFFFAOYSA-N

SMILES

C1=NC(Br)=CC(C)=C1C#N

Safety Information

HS Code 

2933399990

2-BROMO-5-CYANO-4-PICOLINE Usage And Synthesis

Application

6-Bromo-4-methylpyridin-3-carboxynitrile can be used to prepare substituted nitrogen-containing heterocyclic compounds that can be used as inhibitors of ROMK channel activity. Multiple pieces of evidence indicate that inhibition of ROMK channel activity leads to urinary sodium excretion, diuresis, and a decrease in blood pressure. Therefore, ROMK inhibition may provide a novel mechanism for blood pressure regulation and diuresis in patients with hypertension, congestive heart failure, or any other edematous conditions.

2-BROMO-5-CYANO-4-PICOLINE(1003711-35-0)Related Product Information

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