Polyoxyethylene stearate Chemical Properties

Melting point:

47 °C

Flash point:

39 °C

storage temp. 

2-8°C

Water Solubility 

Soluble in water

solubility 

Chloroform (Slighty), Methanol (Slightly)

form 

powder to lump

color 

White to Almost white

Odor

at 100.00?%. mild fatty

Hydrophilic-Lipophilic Balance (HLB)

18.8

LogP

7.629 (est)

EPA Substance Registry System

Polyethylene glycol monostearate (9004-99-3)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

1

RTECS 

MD0907300

HS Code 

3907200000

Hazardous Substances Data

9004-99-3(Hazardous Substances Data)

Toxicity

LD50 oral in rabbit: > 12mL/kg

MSDS

• Language:English Provider:PEG monostearate
• Language:English Provider:SigmaAldrich

Polyoxyethylene stearate Usage And Synthesis

Chemical Properties

Waxy, light-tan solid; nearly odorless. Congealing range 39–45C. Soluble in water, alcohol, ether, and acetone; insoluble in mineral and vegetable oils.

Uses

Polyoxyethylene stearate is an emulsifier and antifoaming agent used in processed foods, fruit jellies, and sauces.

Uses

Pegosperse(R) 1500 MS is a mixture of polyethylene glycol esters. It is compatible with lipophilic compounds due to a higher free fatty acid content. Suggested applications: cosmetic formulations, lubricants.
Pegosperse(R) 1750 MS is a high molecular weight, high HLB surface active agent suggested for use in cosmetic formulations (emulsifier, viscosity modifier) and lubricants (emulsifier).
Pegosperse(R) 400 MS is a multifunctional surface active agent suggested for use in cosmetic formulations, household products, lubricants, textile chemicals, polishes and paper.
PEG-5 stearate, an emulsifier, is listed as particularly applicable for hand and body lotions and creams.

Definition

Polyoxyethylene stearate is a mixture of the monoand diesters of stearic acid and mixed polyoxyethylene diols having an average polymer length of 7.5 oxyethylene units.

brand name

Myrj 53 (ICI Americas).

General Description

Polyoxyethylene (40) stearate is a neutral surfactant.

Safety Profile

Very slightly toxic by ingestion. Questionable carcinogen with experimental tumorigenic data. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. See also other polyethylene glycol monostearate entries and POLYETHYLENE GLYCOL.

in vitro

Polyoxyethylene stearate has been recommended as an additive to the radiolabelled 7H12 Middlebrook TB media and, as such, has been shown to enhance the growth of mycobacteria in the radiometric BACTEC rapid culture system. Polyoxyethylene (50) stearate produces the greatest enhancement in growth and reduction in the time taken to detect growth for M. tuberculosis and polyoxyethylene (30) stearate and polyoxyethylene (JL) stearate for species of mycobacteria other than M. tuberculosis. Polyoxyethylene stearate inhibits P-gp mediated efflux in a concentration-dependent manner mainly by modulating substrate-stimulated P-gp ATPase activity. Polyoxyethylene 40 stearate reduces vinblastine sulfate efllux. The cytotoxicity of vinblastine to K562/ADR cells is significantly enhanced when cotreated with 100 or 150 μg/mL polyoxyethylene 40 stearate.

in vivo

Polyoxyethylene stearate is potentially useful as a pharmaceutical ingredient to improve the oral bioavailability of coadministered P-gp substrates and substrates for certain CYP isoforms. The average tumour volume and weight are significantly less in the polyoxyethylene 40 stearate+vinblastine groups. The inhibition rate for tumor growth is increased from 0.06 (vinblastine group) to 0.84 (vinblastine+polyoxyethylene 40 stearate group).

Polyoxyethylene stearate(9004-99-3)Related Product Information

• alkyl phenyl polyoxyethylene ether
• Diethylene glycol
• Polyethylene glycol monooleate
• Polyethylene Glycol
• Triethylene glycol
• Polyoxyethylene fatty acid
• GLYCERYL MONOSTEARATE
• Glyceryl monostearate
• Ethylene glycol
• 2-Methyl-2,4-pentanediol
• Polyethylene
• Cremophor EL
• C8E3
• triglycerol stearate
• ETHYLENE GLYCOL MONOSTEARATE
• GLYCERYL MONOSTEARATE
• 1,4-Butanediol
• PROPYLENE GLYCOL