Pexiganan Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMF: Slightly soluble,DMSO: Slightly soluble,Ethanol: 12 mg/ml,PBS (pH 7.2): 5 mg/ml

form 

A solid

color 

white to off-white

Sequence

H-Gly-Ile-Gly-Lys-Phe-Leu-Lys-Lys-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Lys-Leu-Leu-Lys-Lys-NH2

Pexiganan Usage And Synthesis

Uses

Treatment of diabetic foot ulcer infections (antibacterial).

brand name

Cytolex (Abbott).

Biological Activity

Pexiganan (MSI-78) is a 22-aa synthetic cationic antimicrobial peptide (AMP), an analog of magainin found in the African clawed frog (Xenopus laevis). Pexiganan is effective against both Gram-positive (staphylococci MIC ≤16 μg/mL, streptococci & methicillin-resistant S. aureus MIC 8-64 μg/mL, S. pyrogenes MIC 16-256 μg/mL) and Gram-negative aerobes (MIC 4-32 μg/mL, E. cloacae MCI 1-128 μg/mL, A. faecalis 4-64 μg/mL) by disrupting bacteria cell wall or membrane.

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