Methotrexate Chemical Properties

Melting point:

93-94° (Jones); mp 87.5-89.5° (Perri, Moore)

Boiling point:

424.9±45.0 °C(Predicted)

Density 

1.309±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

Solid

color 

White to light yellow

Methotrexate Usage And Synthesis

Originator

Lonapalene,Syntex

Uses

Antipsoriatic.

Definition

ChEBI: Lonapalene is an organochlorine compound and a member of naphthalenes.

Manufacturing Process

A solution of sodium nitrate (0.69 g, 10 mmol) in water (5 ml) was added at 0-5°C to a solution of 6-amino-2,3-dimethoxy-1,4-naphthoquinone (1.17 g, 5 mmol) in 5:1 acetic acid:water (25 ml) containing concentrated hydrochloric acid (1.7 ml). A further quantity of sodium nitrite (0.69 g) was then added to the reaction mixture after cooling to -5°C, followed by a solution of cuprous chloride (0.6 g) in concentrated hydrochloric acid (5 ml). The mixture was allowed to warm to room temperature and solid cuprous chloride was added portionwise until the mixture assumed a green color. Water was then added to the reaction mixture and the precipitated yellow solid filtered off, washed with water and recrystallized from methanol:water (2:1) giving 1.01 g of 6-chloro- 2,3-dimethoxy-1,4-naphthoquinone, melting point 93-94°C (from etherpetrolium ether).

Therapeutic Function

Antipsoriatic