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Diclofenac diethylamine

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Diclofenac diethylamine Basic information

Product Name:
Diclofenac diethylamine
Synonyms:
  • 2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid compd. with n-ethylethanamine
  • Diclofenac Diethyl Amine Salt
  • 2-[2-(2,6-dichloroanilino)phenyl]acetic acid
  • Diclofenac diethylamine, >=99%
  • Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, compd. with N-ethylethanamine (1:1)
  • 2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid compd. with n-ethylethanamine (1:1)
  • DICLOFENAC DIETHYLAMINE
  • n-ethylethanamine 2-[(2,6-dichlorophenyl)amino]benzeneacetate
CAS:
78213-16-8
MF:
C18H22Cl2N2O2
MW:
369.29
EINECS:
616-599-2
Product Categories:
  • API
Mol File:
78213-16-8.mol
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Diclofenac diethylamine Chemical Properties

Melting point:
145-148°C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMF: 30 mg/ml; DMSO: 10 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 2 mg/ml
form 
A crystalline solid
color 
White to off-white
Stability:
Hygroscopic
InChI
InChI=1S/C14H11Cl2NO2.C4H11N/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;1-3-5-4-2/h1-7,17H,8H2,(H,18,19);5H,3-4H2,1-2H3
InChIKey
ZQVZPANTCLRASL-UHFFFAOYSA-N
SMILES
C1(=CC=CC=C1CC(=O)O)NC1C(Cl)=CC=CC=1Cl.N(CC)CC
CAS DataBase Reference
78213-16-8(CAS DataBase Reference)
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Diclofenac diethylamine Usage And Synthesis

Uses

Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

in vivo

Diclofenac (3 mg/kg, b.i.d., for 5 days) significantly increases faecal 51Cr excretion in rats, and such effect is also observed in squirrel monkeys after administrated of 1 mg/kg twice daily for 4 days[1].
Diclofenac (10 mg/kg; administered via oral route just prior to induction of inflammation) shows in vivo anti-inflammatory activity in Wistar rats[1].

Animal Model:Male Sprague-Dawley rats (150±200 g)[1]
Dosage:3 mg/kg
Administration:Oral administration, b.i.d., for 5 days
Result:Resulted in a significant increase in faecal 51Cr excretion.
Animal Model:Wistar rats (150-175 g) bearing Formalin-induced rat foot paw edema model[2]
Dosage:10 mg/kg
Administration:Administered via oral route just prior to induction of inflammation
Result:Showed in vivo anti-inflammatory activity (% edema inhibition=29.2, 1 h; 22.2, 3 h; 20, 6 h).

IC 50

Human COX-2: 1.3 nM (IC50, in CHO cells); Human COX-1: 4 nM (IC50, in CHO cells); Ovine COX-2: 0.84 μM (IC50); Ovine COX-1: 5.1 μM (IC50)

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