SUBSTANCE P Chemical Properties

Melting point:

148 °C

Density 

1.42±0.1 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

H₂O: 1 mg/mL

form 

powder

pka

13.26±0.46(Predicted)

color 

white

Water Solubility 

Soluble in water, DMSO, and Acetic Acid.

Sequence

H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2

InChIKey

ADNPLDHMAVUMIW-UHFFFAOYSA-N

Safety Information

WGK Germany 

3

F 

3-10-21

SUBSTANCE P Usage And Synthesis

Chemical Properties

White freeze-dried powder, soluble in water, high purity aqueous solution is very easy to inactivate, adding tween 80, gelatin, human plasma albumin or bovine gammaglobulin can increase its stability; pH greater than 8 is not stable, inactivated by pepsin and pancreatic curdling protease; it is advisable to be stored in a low pH, and filled with nitrogen or add antioxidants to avoid its inactivation.

Uses

Substance P is a neurokinin undecapeptide neurotransmitter and neuromodulator.

Definition

ChEBI: Substance P is a neuropeptide consisting of 11-amino acids. It preferentially activates neurokinin-1 receptors, exterting excitatory effects on central and peripheral neurons and involved in pain transmission. It has a role as a neurotransmitter, a vasodilator agent and a neurokinin-1 receptor agonist. It is a conjugate base of a substance P(3+).

General Description

Substance P is a polypeptide consisting of 11 amino acidresidues. It has been implicated in the transmission of“painful” sensory information through the spinal cord tohigher centers in the central nervous system. Substance Pis localized in the primary afferent sensory fibers. Other pharmacologicaleffects are vasodilatation, stimulation of smoothmuscles, stimulation of salivary secretion, and diuresis. In addition,this neuropeptide contributes to some inflammatory responses.Approximately 50% of the known neuropeptides aresynthesized as biologically inactive glycine extended precursorsthat require a carboxy-terminal posttranslational amidationfor biological activity. Amidation enzymes are responsiblefor the conversion of the carboxyl group of the neuropeptide tothe corresponding amide group and include the two amidatingenzymes peptidylglycine α-monooxygenase (PAM) and peptidylamidoglycolatelyase (PGL), which work sequentially toproduce the inflammatory neuropeptide Substance P from aninactive precursor peptide. Much research is being performedto exploit this mechanism of inflammation.

Biological Activity

Cell permeable: no', 'Primary Target
Substance P receptors', 'Product does not compete with ATP.', 'Reversible: no

storage

-20°C

SUBSTANCE P(33507-63-0)Related Product Information

• SUBSTANCE P
• LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
• ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 3ACOH 5H2O
• GLY-LEU-MET-NH2
• SUBSTANCE P (1-7)
• SUBSTANCE P (2-11)
• SUBSTANCE P (1-9)
• ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-OME
• SUBSTANCE P (5-11)
• SUBSTANCE P (7-11)
• SUBSTANCE P (4-11)
• SUBSTANCE P (1-4)
• PANCREATIC POLYPEPTIDE, RAT
• SUBSTANCE P (6-11)
• Substance P (1-7)(TFA)
• NEUROPEPTIDE Y (13-36), PORCINE SYNTHETI C >97%
• substance P (3-11)
• (LEU31,PRO34)-NEUROPEPTIDE Y (HUMAN, RAT)