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5-Chloro-2,4,6-trifluoropyrimidine

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5-Chloro-2,4,6-trifluoropyrimidine Basic information

Product Name:
5-Chloro-2,4,6-trifluoropyrimidine
Synonyms:
  • 5-CHLORO-2,4,6-TRIFLUOROPYRIMIDINE
  • AKOS BBS-00006250
  • 5-Chloro-2,4,6-Trifluoropyrimide
  • 2,4,6-TRIFLUORO-5-CHLOROPYRIMIDINE
  • 5-CHLORO-2,4,6-TRIFLUORO-PYRIMIDIN
  • Pyrimidine, 5-chloro-2,4,6-trifluoro-
  • 5-Chloro-2,4,6-trifluoropyrimidine,97%
  • 5-Chloro-2,4,6-trifluoropyrimidine >
CAS:
697-83-6
MF:
C4ClF3N2
MW:
168.5
EINECS:
211-807-4
Product Categories:
  • Building Blocks
  • Halogenated Heterocycles
  • Pyrimidine
  • Heterocyclic Building Blocks
  • Pyrimidines
  • Building Blocks
  • PyrimidinesHeterocyclic Building Blocks
  • C4 to C5
  • Chemical Synthesis
  • Fluorinated Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Heterocyclic Fluorinated Building Blocks
  • Other Fluorinated Heterocycles
Mol File:
697-83-6.mol
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5-Chloro-2,4,6-trifluoropyrimidine Chemical Properties

Boiling point:
116 °C(lit.)
Density 
1.626 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.439(lit.)
Flash point:
>230 °F
form 
Liquid
pka
-9.30±0.39(Predicted)
color 
Clear colorless
Specific Gravity
1.626
BRN 
610168
CAS DataBase Reference
697-83-6(CAS DataBase Reference)
EPA Substance Registry System
Pyrimidine, 5-chloro-2,4,6-trifluoro- (697-83-6)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
IRRITANT, MOISTURE SENSITIVE
HS Code 
29335990

MSDS

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5-Chloro-2,4,6-trifluoropyrimidine Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

5-Chloro-2,4,6-trifluoropyrimidine can be used as a starting material to synthesize:

  • 4-azido-5-chloro-2,6-difluoro-pyrimidine by azidation reaction with sodium azide.
  • 5-chloro triphenoxy pyrimidine by reacting with tetraphenoxysilane in the presence of tetra butyl ammonium fluoride (TBAF).
  • 5-chloro-2,6-difluoropyrimidin-4-amine, and 5-chloro-4,6-difluoropyrimidin-2-amine (9:1 ratio) by reacting with ammonia.
  • 5-Chloro-N,N -diethyl-2,6-dipyrimidin-4-amine, by treating with diethylamine and DIPEA.

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