Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Synthetic Anti-infective Drugs >  Antiseptics & Disinfectants Drugs >  2-ETHOXY-6,9-DIAMINOACRIDINE

2-ETHOXY-6,9-DIAMINOACRIDINE

Basic information Safety Supplier Related

2-ETHOXY-6,9-DIAMINOACRIDINE Basic information

Product Name:
2-ETHOXY-6,9-DIAMINOACRIDINE
Synonyms:
  • 2-ETHOXY-6,9-DIAMINOACRIDINE
  • 6,9-DIAMINO-2-ETHOXYACRIDINE
  • 7-ETHOXY-ACRIDINE-3,9-DIAMINE
  • ACRINOL
  • RIVANOL
  • Ethacridine
  • 6,9-DIAMINO-2-ETHOXYACRIDINEHYDROCHLORIDE
  • 7-Ethoxy-3,9-acridinediamine
CAS:
442-16-0
MF:
C15H15N3O
MW:
253.3
EINECS:
207-130-9
Mol File:
442-16-0.mol
More
Less

2-ETHOXY-6,9-DIAMINOACRIDINE Chemical Properties

Melting point:
226°
Boiling point:
396.5°C (rough estimate)
Density 
1.0966 (rough estimate)
refractive index 
1.5700 (estimate)
storage temp. 
2-8°C
pka
11.22±0.10(Predicted)
More
Less

2-ETHOXY-6,9-DIAMINOACRIDINE Usage And Synthesis

Originator

Rivanol,Sopharma

Uses

7-ethoxyacridine-3,9-diamine is used in biological studies for cancer regression by inducing a regeneration-like response by activating expression and/or function of YAP and/or TAZ.

Definition

ChEBI: Ethacridine is a member of acridines.

Manufacturing Process

A mixture of 250 parts by volume of ethylene glycol, 50 parts by weight of 6- nitro-9-chloro-2-ethoxyacridine (obtained by reaction of 52 parts by weight of 30 nitro-4-ethoxy-diphenylamine-6-carboxylic acid with phosphorous oxychloride), 10 parts by weight of ammonium chloride, and 11 parts by weight of urea were heated to 170°C and stirred for 1 hour at 170°-175°C. Subsequently, the whole was cooled to 100°C, the reaction mixture was introduced into 1000 parts by volume of water, rendered acidic to Congo paper by means of hydrochloric acid and the 6-nitro-9-amino-2-ethoxyacridine precipitated was filtered off. By reduction iron according to Bechamp, 6,9- diamino-2-ethoxy-acridine hydrochloride was obtained with yield of 83% as the yellow needles. The base was prepared by adding an equivalent of NaOH. MP: 124°C.
In practice it is usually used as lactate.

Therapeutic Function

Antiseptic, Antibacterial

Purification Methods

It crystallises from 50% EtOH or EtOH as orange-yellow crystals. It also crystallises as a monohydrate m 116-118o. It has a pK2 0 of 11.04 in 50% aqueous EtOH. The methiodide is soluble in H2O and has m 332-334o (dec) (from aqueous Me2CO). [Albert & Gledhill J Soc Chem Ind 61 159 1942, Foye et al. J Pharm Sci 57 1795 1968, Albert & Goldacre J Chem Soc 708 1946, Beilstein 22 II 458, 22 III/IV 6679, 22/12 V 243.]

2-ETHOXY-6,9-DIAMINOACRIDINE Preparation Products And Raw materials

Raw materials

2-ETHOXY-6,9-DIAMINOACRIDINESupplier

LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Alfa Chemistry
Tel
1-516-6625404
Email
support@alfa-chemistry.com
Amadis Chemical Company Limited
Tel
571-89925085
Email
sales@amadischem.com
Suzhou Laihui Biotechnology Co., Ltd.
Tel
180-13160973 18013160973
Email
rywaybio@gmail.com