N-[4-(-Carboxycyclohexylmethyl)]maleimide Chemical Properties

Melting point:

157-158°C

Boiling point:

433.6±18.0 °C(Predicted)

Density 

1.329±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,2-8°C

solubility 

Chloroform, Methanol

form 

Solid

pka

4.80±0.10(Predicted)

color 

Pale Yellow

InChI

InChI=1S/C12H15NO4/c14-10-5-6-11(15)13(10)7-8-1-3-9(4-2-8)12(16)17/h5-6,8-9H,1-4,7H2,(H,16,17)

InChIKey

LQILVUYCDHSGEU-UHFFFAOYSA-N

SMILES

C1(C(O)=O)CCC(CN2C(=O)C=CC2=O)CC1

Safety Information

HS Code 

2925.19.9100

N-[4-(-Carboxycyclohexylmethyl)]maleimide Usage And Synthesis

Description

4-((2,5-Dioxo-2H-pyrrol-1(5H)-yl)methyl)cyclohexanecarboxylic acid contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Chemical Properties

White Solid

Uses

A sulfhydryl crosslinking reagent.

Uses

An amino reactive reagent.

Definition

N-(4-Carboxycyclohexylmethyl)maleimide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.

N-[4-(-Carboxycyclohexylmethyl)]maleimide(64987-82-2)Related Product Information

• Maleimido-Tri(Ethylene Glycol)-Propionic Acid
• Mal-PEG2-COOH
• Mal-PEG4-Acid
• Mal-PEG2-NHS ester
• Bis-Mal-Lysine-PEG4-TFP ester
• Maleimide-PEG4-NHS Ester
• Maleimide-PEG2-NHS Ester
• 3-Maleimidopropionic acid
• Mal-PEG2-acid
• Mal-Amido-PEG4-acid
• 2-MALEIMIDOETHYLAMINE HCL
• 4-MALEIMIDOBUTYRIC ACID
• 1h-pyrrole-2,5-dione, 1-[2-(2-aminoethoxy)ethyl]-, 2,2,2-trifluoroacetate (1:1)
• Maleimide-SS-amine
• Deruxtecan
• SMCC crosslinker
• SULFO-SMCC
• N-[4-(-Carboxycyclohexylmethyl)]maleimide