N-Desmethyl Imatinib Chemical Properties

Melting point:

99-101°C

Density 

1.268±0.06 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

DMF: 16 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 14 mg/ml; Ethanol: 0.20 mg/ml

form 

A lyophilized solid

pka

13.28±0.70(Predicted)

Safety Information

Safety Statements 

24/25

HS Code 

29339900

N-Desmethyl Imatinib Usage And Synthesis

Description

N-desmethyl Imatinib is a major active metabolite of imatinib , an anticancer agent that selectively targets tyrosine kinases, including Bcr-ABL, platelet-derived growth factor receptor (PDGFR), and KIT. N-desmethyl Imatinib is formed when imatinib undergoes demethylation by the cytochrome P450 (CYP) isomer CYP3A4. N-desmethyl Imatinib has the same in vitro potency at Bcr-ABL kinase as imatinib (IC₅₀ = 38 nM for both) but is only present in plasma at 10-15% of the levels of imatinib, indicating the majority of the anticancer activity can be attributed to the parent compound.

Chemical Properties

Off-White to Pale-Yellow Solid

Uses

aminoglycoside antibiotic similar to gentamycin, toxic to bacterial, yeast, higher plant and mammalian cells and to protozoans and helminthes

Uses

anti-epileptic

Uses

N-Desmethyl Imatinib (Imatinib EP Impurity C) is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.

Definition

ChEBI: N-Demethylated piperazine is a member of benzamides.

N-Desmethyl Imatinib(404844-02-6)Related Product Information

• Imatinib
• 1,4-Bis-[4-[4-Methyl-3-[[4-(pyridin-3-yl)pyriMidin-2-yl]aMino]phenyl]carbaMoyl]benzylpiperazine
• iMatinib related substance B
• 2-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZOIC ACID
• Imatinib (Piperidine)-N-oxide
• 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid
• Guanidine, N-(2-methyl-3-nitrophenyl)-
• Imatinib Impurity 7
• N-DESMETHYL IMATINIB
• 4-Chloromethyl-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide
• IMatinib Para-diaMinoMethylbenzene
• Imatinib Meta-methyl-piperazine Impurity
• iMatinib related substance C
• 3-Acetylpyridine
• Imatinib EP Impurity J
• N-(3-GUANIDINO-4-METHYLPHENYL)-4-(METHYLPIPERAZINE-1-YL-METHYL)BENZAMIDE
• Imatinib EP Impurity D
• Imatinib (Pyridine)-N-oxide