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Loperamide

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Loperamide Basic information

Product Name:
Loperamide
Synonyms:
  • loperamide oxide
  • R 58425
  • trans-4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutanamide 1-oxide
  • trans-4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide 1-oxide monohydrate
  • Loperamide EP Impurity F
  • 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide N-oxide
  • LoperaMide-d6 N-Oxide
  • Loperamide impurity-F(EP)
CAS:
106900-12-3
MF:
C29H33ClN2O3
MW:
493.04
Product Categories:
  • Amines
  • Drug Analogues
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Isotope Labelled Compounds
  • Metabolites & Impurities
  • Pharmaceuticals
Mol File:
106900-12-3.mol
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Loperamide Chemical Properties

solubility 
Practically insoluble in water, freely soluble in alcohol and in methylene chloride.
pka
12.94±0.20(Predicted)
Stability:
Hygroscopic
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Safety Information

RIDADR 
UN 2811 6.1 / PGIII
RTECS 
TM4960200
HS Code 
2933399090
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Loperamide Usage And Synthesis

Chemical Properties

White or almost white powder, slightly hygroscopic.

Uses

Loperamide oxide (LOPOX) is a prodrug of Loperamide (LOP). It is concluded that Loperamide oxide administered intraluminally is reduced to Loperamide and has the same antisecretory potency as Loperamide in jejunum and colon.

Uses

Labelled Loperamide oxide (LOPOX). It is a prodrug of Loperamide (LOP). It is concluded that Loperamide oxide administered intraluminally is reduced to Loperamide and has the same antisecretory potency as Loperamide in jejunum and colon.

Definition

ChEBI: Loperamide oxide is a diarylmethane.

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