Loperamide Chemical Properties

storage temp. 

2-8°C

solubility 

Practically insoluble in water, freely soluble in alcohol and in methylene chloride.

pka

12.94±0.20(Predicted)

form 

powder

Stability:

Hygroscopic

Major Application

pharmaceutical

InChI

1S/C29H33ClN2O3/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32(35)20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3

InChIKey

KXVSBTJVTUVNPM-UHFFFAOYSA-N

SMILES

Clc1ccc(cc1)C2(CC[N](=O)(CC2)CCC(c4ccccc4)(c3ccccc3)C(=O)N(C)C)O

Safety Information

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

WGK 1

RTECS 

TM4960200

HS Code 

2933399090

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral

Loperamide Usage And Synthesis

Chemical Properties

White or almost white powder, slightly hygroscopic.

Uses

Loperamide oxide (LOPOX) is a prodrug of Loperamide (LOP). It is concluded that Loperamide oxide administered intraluminally is reduced to Loperamide and has the same antisecretory potency as Loperamide in jejunum and colon.

Uses

Labelled Loperamide oxide (LOPOX). It is a prodrug of Loperamide (LOP). It is concluded that Loperamide oxide administered intraluminally is reduced to Loperamide and has the same antisecretory potency as Loperamide in jejunum and colon.

Definition

ChEBI: Loperamide oxide is a diarylmethane.

Loperamide(106900-12-3)Related Product Information

• Trimethylamine N-oxide
• 1-(4-CHLORO-PHENYL)-3-DIMETHYLAMINO-PROPAN-1-OL
• (R)-1-(4-CHLOROPHENYL)-1-PROPANOL
• fenpipramide
• 4-(4-CHLOROPHENYL)PIPERIDINE
• Alverine
• 4-(4-Chlorophenyl)piperidin-4-ol
• (Diphenyl-3,3 propyl)-1 phenyl-4 piperidine chlorhydrate [French]
• Loperamide
• Trimethylamine N-oxide dihydrate
• 2,2-DIPHENYLPROPYLAMINE HYDROCHLORIDE
• TRIETHYLAMINE N-OXIDE
• DIPHENAMID
• DESMETHYL LOPERAMIDE
• Loperamide