Obtusifolin Chemical Properties

Melting point:

242-243℃

Boiling point:

528.0±50.0 °C(Predicted)

Density 

1.448±0.06 g/cm3 (20 ºC 760 Torr)

storage temp. 

2-8°C

solubility 

DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml

form 

A solid

pka

6.60±0.20(Predicted)

color 

Yellow to orange

Obtusifolin Usage And Synthesis

Chemical Properties

Orange-yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Cassia seed.

Uses

Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway[1]. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein[2].

Definition

ChEBI: Obtusifolin is a dihydroxyanthraquinone.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

IC 50

NF-κB

References

[1] Choi BS, et al. Obtusifolin isolated from the seeds of Cassia obtusifolia regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via affecting NF-κB pathway. Phytother Res. 2019 Apr;33(4):919-928. DOI:10.1002/ptr.6284
[2] Hsu YL, et al. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein. J Agric Food Chem. 2014 Dec 10;62(49):11933-40. DOI:10.1021/jf5042905

Obtusifolin(477-85-0)Related Product Information

• Anthraquinone
• Emodin 8-glucoside
• PURPURIN
• DAMNACANTHAL
• (BETA,BETA-DIMETHYLACRYL)SHIKONIN
• Emodin-8-glucoside
• Chrysophal 8-O-glucoside
• AURANTIO-OBTUSIN
• Chrysophanein
• rubrofusarin gentiobioside
• PLUMBAGIN
• 1,7-Dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione
• Aurantio-obtusin-6-O-β-D-glucoside
• Chrysophanic acid
• GYNOSTEMMA PENTAPHYLLUM P.E.