2-Chloro-6-fluoroanisole Chemical Properties

Boiling point:

186.4±20.0 °C(Predicted)

Density 

1.239±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Benzene (Slightly), Chloroform, Methanol (Slightly)

form 

Oil

color 

Clear Colourless

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

PackingGroup 

III

HS Code 

2909309090

2-Chloro-6-fluoroanisole Usage And Synthesis

Chemical Properties

Colorless liquid

Synthesis

GENERAL STEPS: Iodomethane (850 μL, 13.646 mmol) and potassium carbonate (943 mg, 6.824 mmol) were sequentially added to a solution of tetrahydrofuran (10 mL) containing 2-chloro-6-fluorophenol (1.0 g, 6.824 mmol). The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the mixture was transferred to a partition funnel and extracted with ether (50 mL) and water (50 mL) by partition. The organic phase was separated and washed with water (2 x 20 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 2-chloro-6-fluoroanisole as a colorless liquid in 94% yield (1.03 g).1H NMR (400 MHz, CD3OD) δ: 3.90-3.91 (s, 3H), 7.01-7.12 (m, 2H), 7.18-7.21 (m, 1H).

References

[1] Patent: WO2007/34325, 2007, A1. Location in patent: Page/Page column 47

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