2-Chloro-5-iodobenzotrifluoride Chemical Properties

Melting point:

28 °C

Boiling point:

235 ºC

Density 

1.952

Flash point:

28 °C

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

powder to lump

color 

White to Light yellow

InChIKey

MCIFWVOVVPVBRJ-UHFFFAOYSA-N

Safety Information

HS Code 

2903998090

2-Chloro-5-iodobenzotrifluoride Usage And Synthesis

Chemical Properties

liquid

Synthesis

General procedure for the synthesis of 2-chloro-5-iodobenzotrifluoride from 2-trifluoromethyl-4-iodophenol: 4-iodo-2-trifluoromethylphenol (10 mmol) obtained in 1.1 was dissolved in 20 mL of N,N-dimethylformamide (DMF). Subsequently, phosphorous trichloride (10.5 mmol) was added, and the reaction system was placed in a microwave reactor, heated to 130 °C, and kept for 1 hour. After the reaction was completed, the system was cooled to room temperature, 30 mL of water was added and stirred for 10 minutes. The reaction mixture was extracted with 30 mL of dichloromethane and the organic phase was dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure. Purification by fast column chromatography using petroleum ether as eluent gave 2.1 g of light yellow solid 1-chloro-4-iodo-2-trifluoromethylbenzene in 69% yield.

References

[1] Patent: CN108184888, 2018, A. Location in patent: Paragraph 0014
[2] Patent: CN108338175, 2018, A. Location in patent: Paragraph 0019
[3] Patent: CN108353907, 2018, A. Location in patent: Paragraph 0015-0016
[4] Patent: CN108353920, 2018, A. Location in patent: Paragraph 0014
[5] Patent: CN108432777, 2018, A. Location in patent: Paragraph 0016

2-Chloro-5-iodobenzotrifluoride(260355-20-2)Related Product Information

• Benzotrifluoride
• 2-Methylbenzotrifluoride
• 1,4-Bis(trifluoromethyl)-benzene
• Ethylbenzene
• Epichlorohydrin
• 2-Chloro-5-nitrobenzotrifluoride
• 4-Chlorotoluene
• 3-Fluorobenzotrifluoride
• 2-Chloro-5-trifluoromethylpyridine
• Allylbenzene
• Benzene
• λ-Cyhalothrin
• FLUOROLUBE GREASE, GR-362
• Benzyl chloride
• Chloroacetic acid
• Difluorochloromethane
• 3-Iodobenzotrifluoride
• Trifluoromethyl