Glycine tert butyl ester hydrochloride Chemical Properties

Melting point:

141-143 °C(lit.)

storage temp. 

-20°C

solubility 

H₂O: 0.1 g/mL, clear, colorless

form 

Crystalline Powder

color 

White

Water Solubility 

Soluble in methanol and water

BRN 

3989048

Major Application

peptide synthesis

InChI

InChI=1S/C6H13NO2.ClH/c1-6(2,3)9-5(8)4-7;/h4,7H2,1-3H3;1H

InChIKey

OSWULUXZFOQIRU-UHFFFAOYSA-N

SMILES

C(C)(C)(C)OC(=O)CN.Cl

CAS DataBase Reference

27532-96-3(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

24/25

WGK Germany 

3

F 

10-23

TSCA 

No

HS Code 

29224995

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Glycine tert butyl ester hydrochloride Usage And Synthesis

Chemical Properties

Glycine tert butyl ester hydrochloride is Crystalline

Uses

Glycine tert butyl ester hydrochloride is a substituted Glycine (G615990) used as parakeratosis inhibitor and external composition for skin.

Uses

Glycine t-butyl ester hydrochloride is a substituted Glycine used as parakeratosis inhibitor.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

Add 1400L of tert-butyl acetate, 105KG of glycine to 2000L reaction tank, and add 180KG of perchloric acid at a uniform rate. Reaction at 0-10 ?? about 48-72 hours, the reaction process TLC to monitor the reverse situation, to be glycine reaction more than 90%, with 4 N sodium hydroxide aqueous solution to adjust the PH6.5-7.5, separated from the organic layer, the aqueous layer continues to be extracted with tert-butyl acetate, to be basically extracted to 95% of the products of water, combined with all the product layer, to be extracted to 95% of the product, and the water layer, to be extracted to 95% of the product. After 95% of the product was extracted, all the product layers were combined and washed with brine to TLC pure, then 1500L of tert-butyl glycinate / tert-butyl ethyl ester solution was obtained, tert-butyl glycinate was concentrated and recycled to obtain tert-butyl glycinate 180KG, 100L of ethyl ethyl ester was added, and the product was passed through the HCl to PH0.5, then stirred to cool and cold crystallize, and centrifugally washed to obtain tert-butyl glycinate hydrochloride 182KG.

Glycine tert butyl ester hydrochloride(27532-96-3)Related Product Information

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