Corynoxine
Corynoxine Basic information
- Product Name:
- Corynoxine
- Synonyms:
-
- (16E)-16,17-Didehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester
- Corynoxine
- Corynoxine A
- Corynoxan-16-carboxylicacid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (16E)-
- Corynoxine, 99.5%
- Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1'S,6'S,7'S,8'aS)-
- (E)-methyl 2-((1'S,6'S,7'S,8a'S)-6'-ethyl-2-oxo-3',5',6',7',8',8a'-hexahydro-2'H-spiro[indoline-3,1'-indolizin]-7'-yl)-3-methoxyacrylate
- Corynoxine, 10 mM in DMSO
- CAS:
- 6877-32-3
- MF:
- C22H28N2O4
- MW:
- 384.47
- EINECS:
- 211-708-6
- Mol File:
- 6877-32-3.mol
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Corynoxine Chemical Properties
- Melting point:
- 166-168℃
- Boiling point:
- 560.8±50.0 °C(Predicted)
- Density
- 1.23
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 100 mg/mL (260.10 mM);Water : < 0.1 mg/mL (insoluble)
- pka
- 13.61±0.60(Predicted)
- form
- Cryst.
- color
- White to off-white
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Corynoxine Usage And Synthesis
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the Rubiaceae plant Uncaria rhynchophylla.
Uses
Corynoxine is an indole alkaloid extracted from Uncaria plants, and have been shown to affect locomotor response in mice . Research points to a mediation of the central dopaminergic system.
Definition
ChEBI: A natural product found in Uncaria macrophylla.
in vivo
Corynoxine (100-100 mg/kg; oral gavage) exhibits prolongation of the thiopental-induced hypnosis in mice[2].
Corynoxine (10-100 μM for 12 h) induces autophagy in drosophila[1].
target
Akt | mTOR | Autophagy
CorynoxineSupplier
Shandong Xiya Chemical Co., Ltd
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China Langchem Inc.
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