(9S)-9-Amino-9-deoxoerythromycin Chemical Properties

Melting point:

123-127°C

Boiling point:

810.3±65.0 °C(Predicted)

Density 

1.19±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

DMF: 15 mg/ml; DMSO: 15 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml

form 

A solid

pka

13.41±0.70(Predicted)

color 

White to off-white

Safety Information

Hazard Codes 

Xi,N

Risk Statements 

41-50/53

Safety Statements 

26-39-60-61

Toxicity

mouse,LD50,intraperitoneal,120mg/kg (120mg/kg),European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 13, Pg. 83, 1978.

(9S)-9-Amino-9-deoxoerythromycin Usage And Synthesis

Chemical Properties

(9S)-9-Amino-9-deoxoerythromycin is White Solid

Uses

(9S)-9-Amino-9-deoxoerythromycin is a semi-synthetic analogue of erythromycin prepared by reduction of erythromycin oxime. (9S)-9-Amino-9-deoxoerythromycin is a potent antibiotic, however the introduction of the amino- moiety increases the compound’s polarity and is disadvantageous for in vivo use. This limitation was overcome by the synthesis of dirithromycin, a Schiff base pro-drug that dissociates in vivo to erythromycylamine.

Uses

Erythromycylamine is a semi-synthetic analogue of erythromycin prepared by reduction of erythromycin oxime. Erythromycylamine is a potent antibiotic, however the introduction of the amino- moiety increases the compound’s polarity and is disadvantageous for in vivo use. This limitation was overcome by the synthesis of dirithromycin, a Schiff base pro-drug that dissociates in vivo to erythromycylamine.

Uses

(9S)-9-Amino-9-deoxoerythromycin is a metabolite of Dirithromycin; an antibiotic

Definition

ChEBI: A macrolide antibiotic that is erythromycin A in which the ketone group has been converted to the corresponding imine and then reduced to give the corresponding amino compound (the 9S diastereoisomer).

(9S)-9-Amino-9-deoxoerythromycin(26116-56-3)Related Product Information

• Cyprodinil
• Pyrimethanil
• Dirithromycin impurity
• N-Demethyl-N-Propanoyl Erythromycin
• erythronolide B
• (9S)-9-Amino-9-deoxoerythromycin-d3
• (9S)-9-[[[4-(Acetylamino)phenyl]sulfonyl]amino]-9-deoxoerythromycin
• (9S)-9-[[(4-Chlorophenyl)sulfonyl]amino]-9-deoxoerythromycin
• (9S)-9-[[(4-Bromophenyl)sulfonyl]amino]-9-deoxoerythromycin
• Dirithromycin
• (9S)-9-Amino-9-deoxoerythromycin