5-Aminolevulinic acid hexyl ester hydrochloride Chemical Properties

Melting point:

94°

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO:41.0(Max Conc. mg/mL);162.86(Max Conc. mM)

form 

A solid

color 

White to off-white

Water Solubility 

H2O: 20mg/mL, clear

Sensitive 

Light Sensitive/Hygroscopic

InChI

InChI=1S/C11H21NO3.ClH/c1-2-3-4-5-8-15-11(14)7-6-10(13)9-12;/h2-9,12H2,1H3;1H

InChIKey

LZYXPFZBAZTOCH-UHFFFAOYSA-N

SMILES

C(=O)(OCCCCCC)CCC(=O)CN.Cl

Safety Information

Hazard Codes 

Xi

HS Code 

2922500090

5-Aminolevulinic acid hexyl ester hydrochloride Usage And Synthesis

Uses

Diagnostic agent for the diagnosis of bladder cancer.

Uses

5-Aminolevulinic Acid Hexyl Ester Hydrochloride is used in treating domestic animal cancers through programmed cancer cell death and apoptosis-stimulating proteins.

Biological Activity

Hexaminolevulinate (HAL) hydrochloride is a hexyl ester of 5-Aminolevulinic acid (ALA), a precursor to porphyrins including the photosensitizer protoporphyrin IX (PPIX). Hexaminolevulinate is more lipophilic than ALA, and is 50–100 times more efficient than ALA at inducing PpIX, which accumulates preferentially in neoplastic cells. Hexaminolevulinate administration followed by light activation has been used for fluorescence cystoscopy to enhance detection of bladder cancer, in particular carcinoma in situ (CIS). Hexaminolevulinate is also being studied for use in cancer photodynamic therapy. Hexaminolevulinate followed by irradiation produced DNA oxidative damage and apoptosis.

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