L-NORADRENALINE HYDROCHLORIDE
L-NORADRENALINE HYDROCHLORIDE Basic information
- Product Name:
- L-NORADRENALINE HYDROCHLORIDE
- Synonyms:
-
- L-ARTERENOL HYDROCHLORIDE
- (-)-ARTERENOL HYDROCHLORIDE
- L-NOREPINEPHRINE HYDROCHLORIDE
- 1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]-, hydrochloride (1:1)
- L-NORADRENALINE HYDROCHLORIDE
- aktaminhydrochloride
- alpha-(aminomethyl)-3,4-dihydroxy-,hydrochloride,(-)-benzylalcoho
- levophedhydrochloride
- CAS:
- 329-56-6
- MF:
- C8H11NO3.ClH
- MW:
- 205.64
- EINECS:
- 206-345-5
- Mol File:
- 329-56-6.mol
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L-NORADRENALINE HYDROCHLORIDE Chemical Properties
- Melting point:
- ~150 °C (dec.)
- alpha
- D25 -40° (c = 6)
- storage temp.
- 2-8°C
- solubility
- Very soluble in water, slightly soluble in ethanol (96 per cent). It becomes coloured on exposure to air and light.
- form
- Solid
- color
- X-form-crystals
- InChI
- InChI=1S/C8H11NO3.ClH/c9-4-8(12)5-1-2-6(10)7(11)3-5;/h1-3,8,10-12H,4,9H2;1H/t8-;/m0./s1
- InChIKey
- FQTFHMSZCSUVEU-QRPNPIFTSA-N
- SMILES
- C1(O)=CC=C([C@@H](O)CN)C=C1O.[H]Cl
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Safety Information
- Hazard Codes
- T,C,F
- Risk Statements
- 25-34-11
- Safety Statements
- 45-36/37/39-26-16
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- DN6475000
- F
- 3-8-10-23
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Toxicity
- LD50 orl-rat: 132 mg/kg AIPTAK 180,155,69
MSDS
- Language:English Provider:SigmaAldrich
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L-NORADRENALINE HYDROCHLORIDE Usage And Synthesis
Chemical Properties
White or brownish-white, crystalline powder.
Uses
Alpha-adrenoceptor agonist.
Safety Profile
Poison by ingestion,subcutaneous, and intraduodenal routes. When heated todecomposition it emits very toxic fumes of HCl and NOx.
in vivo
Norepinephrine hydrochloride can be used to induce cardiomyopathy[5][6]
Induced Cardiomyopathy Model[5][6]
Background
Norepinephrine hydrochloride is a potent growth factor for cardiomyocytes. Long-term infusion of subhyperbaric doses of Norepinephrine hydrochloride in animals can cause increases in myocardial mass and left ventricular wall thickness. Norepinephrine hydrochloride activates the Raf-1 kinase/MAP kinase cascade through α1- and β-adrenergic stimulation, and signaling pathways from both receptors synergistically induce cardiomyocyte hypertrophy.
Specific Modeling Methods
Rat: Spragues-Dawley rats ? adult (6 months old) ? male
Administration: Continuously injected via an osmotic minipump ? 100 μg/kg/h or 200 μg/kg/h (Norepinephrine)
Modeling Indicators
Molecular changes: Left ventricular Dnmt activity ↑; ROS generation ↑; lactate dehydrogenase release ↑; dystrophin expression ↑; FHL2 protein expression ↓
Gene Expression: Expression of Dnmt1, 3a, and 3b ↑; mRNA expression of fetal genes ANP, BNP, and βMHC in left ventricle ↑
Phenotypic observation: Myocardial infarction area ↑; blood pressure continues to rise; left ventricular mass ↑; left ventricular development pressure ↓; cardiac contractility ↓. Cardiac hypertrophy.
Correlated Product(s): /
Opposite Product(s): 5-Aza-2’-deoxycytidine (HY-A0004), Prazosin (HY-B0193), Propranolol (HY-B0573B)
IC 50
α1-adrenergic receptor; α2-adrenergic receptor; Beta-1 adrenergic receptor; Microbial Metabolite; Human Endogenous Metabolite
Purification Methods
Recrystallise arterenol from isoPrOH and store it in the dark as it is oxidised under light (see preceding entry). [Tullar J Am Chem Soc 70 2067 1948, Beilstein 13 III 2382.]
L-NORADRENALINE HYDROCHLORIDESupplier
Xinxiang City Oran Biotechnology Co. Ltd. Gold
- Tel
- 0373-6766851 18568539857
- alchemic516@163.com
Hangzhou Yuhao Chemical Technology Co., Ltd
- Tel
- 0571-82693216
- info@yuhaochemical.com
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
Guangzhou Isun Pharmaceutical Co., Ltd
- Tel
- 020-39119399 18927568969
- isunpharm@qq.com
Wuhan Dahua Pharmaceutical Co., Ltd.
- Tel
- 027-59262863 13277907145 3091977954
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L-NORADRENALINE HYDROCHLORIDE(329-56-6)Related Product Information
- Phenylephrine hydrochloride
- (-)-N-ISOPROPYL-L-NORADRENALINE HYDROCHLORIDE
- Epinephrine Hydrochloride
- L-NORADRENALINE HYDROCHLORIDE
- Norepinephrine
- 3,4-DIHYDROXYBENZYL ALCOHOL
- N-ISOPROPYL-DL-NORADRENALINE HYDROCHLORIDE
- N-ISOPROPYL-DL-NORADRENALINE HYDROCHLORIDE
- DL-NORADRENALINE HYDROCHLORIDE
- PHOMOPSIN A
- BICUCULLINE METHYLCHLORIDE (-), [METHYL-14C]
- BICUCULLINE METHYLCHLORIDE (-), [METHYL-3H]
- (-)-(1R,3S)-3-ADAMANTYL-1-(AMINOMETHYL)-3,4-DIHYDRO-5,6-DIHYDROXY-1H-2-BENZOPYRAN HYDROCHLORIDE
- CIS-(+/-)-1-(AMINOMETHYL)-3,4-DIHYDRO-3-PHENYL-1H-2-BENZOPYRAN-5,6-DIOL HYDROCHLORIDE
- (-)-BICUCULLINE METHCHLORIDE, 1(S),9(R)
- NOREPINEPHRINE HYDROCHLORIDE, DL-, [7-3H]
- 6-FLUORONOREPINEPHRINE HYDROCHLORIDE