1H-Pyrazole-3-carboxamide,1,5-dimethyl-(9CI) Chemical Properties

Boiling point:

288.7±28.0 °C(Predicted)

Density 

1.28±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

15.85±0.50(Predicted)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-37/39

HS Code 

29339900

1H-Pyrazole-3-carboxamide,1,5-dimethyl-(9CI) Usage And Synthesis

Chemical Properties

White crystals

Synthesis

General procedure for the synthesis of 1,5-dimethyl-1H-pyrazole-3-carboxamide from 1,5-dimethyl-1H-pyrazole-3-carboxylic acid: 1,5-dimethyl-1H-pyrazole-3-carboxylic acid (10 g, 71.43 mmol) was mixed with sulfinyl chloride (SOCl2, 25.5 g, 214.29 mmol), and the reaction was carried out at reflux for 2 hours. After completion of the reaction, the mixture was concentrated under vacuum. Subsequently, 200 mL of ammonia (NH3-H2O) was slowly added dropwise to the residue at 0 °C and the reaction was carried out under stirring. At the end of the reaction, the solid product was collected by filtration to afford 8 g (81% yield) of 1,5-dimethyl-1H-pyrazole-3-carboxamide as a white solid.

References

[1] Patent: WO2009/139834, 2009, A1. Location in patent: Page/Page column 128-129

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