Lercanidipine Chemical Properties

Melting point:

118-120°C

Boiling point:

712.5±60.0 °C(Predicted)

Density 

1.177±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

Powder

pka

8.66±0.50(Predicted)

color 

Light yellow to yellow

CAS DataBase Reference

100427-26-7(CAS DataBase Reference)

Lercanidipine Usage And Synthesis

Description

Lerdip was launched in the Netherlands for hypertension. It is prepared in four steps, the last of which is a Hantsch reaction of 1-[(3,3-diphenyl)-N-methylpropylamino]- 2-methyl-2-propyl-2-(3-nitrobenzylidene)acetoacetate with methyl 3-aminocrotonate. This compound was designed to be very lipophilic which imparts the drug with a gradual onset and a long duration of action as a result of prolonged exposure to receptors by partitioning into membranes. It is an antagonist of L-type calcium channels with no activity in smooth muscle cells, is tissue selective, lacks any myocardial contractility impairment, has no neuroendocrine activation, and has negligible affinity for neurotransmitter receptors such as α₁- and α₂-adrenergic receptors. While sold as a racemate, the calcium channel activity is found in the (S)- isomer with the (R)-isomer being 2-orders of magnitude less active. It has an increased cardiac contractility index which is much more than Nitrendipine or nifedipine. The good selectivity causes a reduction in blood pressure with no negative inotropic effects.

Originator

Recordati (Italy)

Uses

Antihypertensive compound; calcium channel blocker.

Definition

ChEBI: Lercanidipine is a diarylmethane.

brand name

Cardiovasc (Recor dati, Italy); Carmen (Recordati, Italy); Corifeo (Recordati, Italy); Lercadip (Recordati, Italy); Lercan (Recordati, Italy); Lercapin (Recordati, Italy); Lercaton (Recordati, Italy); Lerkamen (Recordati, Italy); Lerzam (Recordati, Italy); Renovia (Recordati, Italy); Vasodip (Recordati, Italy); Zandip (Recordati, Italy); Zanicor (Recordati, Italy).

Lercanidipine(100427-26-7)Related Product Information

• Dimethyl sulfate
• Dimethyl carbonate
• Dimethyl ether
• Dacthal
• ETHANE
• 2,6-Lutidine
• Dimethyl sulfoxide
• Dimethyl disulfide
• Chlorodimethylphenylsilane
• Dimethyl fumarate
• Poly(dimethylsiloxane)
• 2,5-PYRIDINEDICARBOXYLIC ACID
• N,N-Dimethylformamide
• N-Ethylmethylamine
• Quinolinic acid
• Nitrendipine
• tert-Butyl methacrylate
• Lercanidipine mainring