Basic information Safety Supplier Related

safracin B

Basic information Safety Supplier Related

safracin B Basic information

Product Name:
safracin B
Synonyms:
  • safracin B
  • 2-Amino-N-[(6,7,9,10,13,14,14a,15-octahydro-1,7-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-6,15-epimino-5H-isoquino[3,2-b][3]benzazocin-9-yl)methyl]propionamide
  • Propanamide, 2-amino-N-[[(6S,7S,9R,14aS,15R)-6,7,9,10,13,14,14a,15-octahydro-1,7-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-6,15-imino-5H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-, (2S)-
  • Antibiotic EM 5519
  • Antibiotic Y 16482-alpha
CAS:
87578-99-2
MF:
C28H36N4O7
MW:
540.61
Mol File:
87578-99-2.mol
More
Less

safracin B Chemical Properties

Boiling point:
755.1±60.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 20 mg/ml)
pka
9.75±0.70(Predicted)
form 
solid
color 
Yellow-green
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
More
Less

safracin B Usage And Synthesis

Description

Safracin B (87578-99-2) is a novel antibiotic of the saframycin family produced by?Pseudomonas fluorescens.1?Safracin B displays antitumor activity against L1210 and P388 leukemias and B16 melanoma. Compared with safracin A, the toxic and effective doses were much lower. Safracin B also prolonged the life of tumor-bearing mice to a greater extent than safracin A.2

Uses

Safracin B is a new antibiotics from the family of Safracin produced by Pseudomonas fluorescens A2-2. Safracin B is an antibiotic that exhibits anti-tumor properties.

in vivo

Safracin B (0.005-5 mg/kg/day; for 9 days) prolongs the life span of tumor-bearing mice and shows antitumor activity against L1210 and P388 leukemias and B16 melanoma in Female BALB/c x DBA/2 F1 (CD2F1) mice weighing 19-24 g[2].
The LD50 is 7.3 mg/kg with safracin B in normal CD2F1 mice by ip administration[2].

References

[1] Y IKEDA. Safracins, new antitumor antibiotics. I. Producing organism, fermentation and isolation.[J]. Journal of Antibiotics, 1983, 36 10: 1279-1283. DOI:10.7164/antibiotics.36.1279
[2] T OKUMOTO. Activity of safracins A and B, heterocyclic quinone antibiotics, on experimental tumors in mice.[J]. Journal of Antibiotics, 1985, 38 6: 767-771. DOI:10.7164/antibiotics.38.767

safracin BSupplier

INTERCHEMIE NANJING PHARMATECH CO., LTD
Tel
13656237714 13656237714;
Email
xiaokunfu@kyyykj.com
Shanghai Haozhixiang Biotechnology Co., Ltd
Tel
526763801 13301653310
Email
526763801@qq.com
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
BOC Sciences
Tel
+1-631-485-4226
Email
inquiry@bocsci.com
More
Less

safracin B(87578-99-2)Related Product Information