psoralidin Chemical Properties

Melting point:

290-292°

Boiling point:

458.8±34.0 °C(Predicted)

Density 

1.383±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

DMSO: soluble5mg/mL, clear (warmed)

form 

powder

pka

8.70±0.20(Predicted)

color 

white to beige

InChIKey

YABIJLLNNFURIJ-UHFFFAOYSA-N

Safety Information

WGK Germany 

3

HS Code 

2932.20.4500

psoralidin Usage And Synthesis

Description

Psoralidin is a furanocoumarin isolated from the seeds of P. corylifolia, a medicinal plant found in southeastern Asia, that has been shown to induce cytotoxicity against various cancer cells. Through TNF-related apoptosis-inducing ligand-mediated events, psoralidin at 50 μM can induce the death of HeLa cancer cells. It also can induce apoptosis of androgen-dependent (LNCaP, C4-2B) and androgen-independent (DU-145, PC-3) prostate cancer cells and inhibit the growth of PC-3 xenograft tumors in nude mice.

Uses

Psoralidin is an antibacterial and antioxidant reagent.

Definition

ChEBI: A member of the class of coumestans that is coumestan substituted by hydroxy groups at positions 3 and 9 and a prenyl group at position 2 respectively.

References

[1] yang h j, youn h s, seong k m, et al. psoralidin, a dual inhibitor of cox-2 and 5-lox, regulates ionizing radiation (ir)-induced pulmonary inflammation[j]. biochemical pharmacology, 2011, 82(5): 524-534.
[2] chiou w f, don m j, liao j f, et al. psoralidin inhibits lps-induced inos expression via repressing syk-mediated activation of pi3k-ikk-iκb signaling pathways[j]. european journal of pharmacology, 2011, 650(1): 102-109.
[3] bronikowska j, szliszka e, jaworska d, et al. the coumarin psoralidin enhances anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand (trail)[j]. molecules, 2012, 17(6): 6449-6464.

psoralidin(18642-23-4)Related Product Information

• Hederagenin
• Naringin
• MERANZIN
• AURANTIO-OBTUSIN
• 6-Hydroxypurine
• Emodin-3-methyl ether
• Psoralen
• HINOKIFLAVONE
• L-Theanine
• Formononetin
• Toosendanin
• TYROSINASE
• 7,8-Dihydroxycoumarin
• Gallic acid monohydrate
• epiberberine
• psoralidin
• COUMESTROL
• neoglycyrol