GW0742
GW0742 Basic information
- Product Name:
- GW0742
- Synonyms:
-
- 2-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy)
- GW 0742X
- GW 610742
- GWdelta 0742
- 2-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylpheno
- GW0742
- [4-[[[2-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-5-THIAZOLYL]METHYL]THIO]-2-METHYLPHENOXY]ACETIC ACID
- 4-[2-(3-FLUORO-4-TRIFLUOROMETHYL-PHENYL)-4-METHYL-THIAZOL-5-YLMETHYLSULFANYL]-2-METHYL-PHENOXY-ACETIC ACID
- CAS:
- 317318-84-6
- MF:
- C21H17F4NO3S2
- MW:
- 471.49
- EINECS:
- 1532714-185-1
- Product Categories:
-
- Inhibitors
- Intermediates & Fine Chemicals
- All Inhibitors
- Pharmaceuticals
- Intracellular receptor
- Inhibitor
- 317318-84-6
- SARMS
- Mol File:
- 317318-84-6.mol
GW0742 Chemical Properties
- Melting point:
- 134.5-135.5 °C
- Boiling point:
- 591.5±60.0 °C(Predicted)
- Density
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >5 mg/mL
- form
- solid
- pka
- 3.17±0.10(Predicted)
- color
- white
- InChI
- InChI=1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28)
- InChIKey
- HWVNEWGKWRGSRK-UHFFFAOYSA-N
- SMILES
- C(O)(=O)COC1=CC=C(SCC2SC(C3=CC=C(C(F)(F)F)C(F)=C3)=NC=2C)C=C1C
MSDS
- Language:English Provider:SigmaAldrich
GW0742 Usage And Synthesis
Description
GW0742 is a PPARδ/β agonist very similar in molecular structure to GW501516 (Cardarine) — with the exception of one atom. It is often mentioned in comparison with Cardarine. This drug is mostly used by athletes to improve their stamina. The fat affecting properties of GW0742 also make it a good promoter of energy in the body. Additionally, this drug helps increase the oxidative abilities of your body muscles.
Chemical Properties
Light Yellow Solid
Uses
GW0742 is a small molecule agonist of the human Peroxisome Proliferator-Activated Recept δ (PPAR δ). It shows an EC50 of 1.1 nM against PPAR δ with 100-fold selectivity over the other human subtypes.
Definition
ChEBI: GW 0742 is a monocarboxylic acid.
Biological Activity
GW 0742 is a potent and highly selective PPARδ agonist. EC50 values are 0.001, 1.1 and 2 μM for transactivation of human PPARδ, -α, and -γ receptors respectively. Neuroprotective in rat cerebellar granule neuronal cultures after brief (12-hour) exposure but exhibits inherent toxicity after prolonged (48-hour) incubation. Increases rate of fatty acid oxidation and protects against ischemia/reperfusion injury in neonatal and adult cardiomyocytes.
storage
Desiccate at +4°C
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