Basic information Safety Supplier Related

beta-endorphin (6-31)

Basic information Safety Supplier Related

beta-endorphin (6-31) Basic information

Product Name:
beta-endorphin (6-31)
Synonyms:
  • beta-endorphin (6-31)
  • b-Lipotropin (64-89) (huMan)
  • H-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu-OH
  • 6-31-β-Endorphin (human)
  • 6-31-β-Endorphin (sheep), 27-L-tyrosine-31-L-glutamic acid-
  • 4 β-Endorphin (6-31) (human)
  • 6-31-b-Endorphin (sheep),27-L-tyrosine-31-L-glutamic acid
  • β-Lipotropin (64-89) (human)
CAS:
77761-27-4
MF:
C131H218N34O40
MW:
2909.36
Mol File:
77761-27-4.mol
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beta-endorphin (6-31) Chemical Properties

Boiling point:
2671.5±65.0 °C(Predicted)
Density 
1.294±0.06 g/cm3(Predicted)
Sequence
Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu
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beta-endorphin (6-31) Usage And Synthesis

Uses

β-Endorphin, an endogenous opioid neuropeptide, is an opioid receptor agonist. β-Endorphin binds preferentially to μ-opioid receptors and is produced in certain neurons of the central and peripheral nervous system and is one of three endorphins produced in humans. β-Endorphin can be used to reduce stress and maintain homeostasis in the body and is involved in neurological pain perception regulation[1].

in vivo

β-Endorphin (0.03 to 1.00?μg/kg, i.p., once) impairs retention of a one-trial inhibitory avoidance task in a dose-dependent manner in male Swiss mice immediately post-training. Also, it works in the process of memory consolidation[1].

Animal Model:Adult male Swiss mice (22-25 g)[1]
Dosage:0.03, 0.10, 0.30 or 1.00 μg/kg
Administration:i.p., once
Result:Significantly impaired retention at the doses of 0.03 and 0.10?μg/kg while not significantly affect retention as compared with the control group at the two higher doses of 0.30 and 1.00?μg/kg , but tended to increase retention as compared with the dose of 0.10?μg/kg.
Increased latencies to step-through at the two higher doses of 0.30 and 1.00?μg/kg but no effect at lower doses.

References

[1] Introini IB, et al. The impairment of retention induced by beta-endorphin in mice may be mediated by a reduction of central cholinergic activity. Behav Neural Biol. 1984 Jul;41(2):152-63. DOI:10.1016/s0163-1047(84)90527-2

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beta-endorphin (6-31)(77761-27-4)Related Product Information